Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography

Porous polymer coatings are used to control drug release from pharmaceutical products. The coating covers a drug core and depending on the porous structure, different drug release rates are obtained. This work presents mass transport simulations performed on porous ethyl cellulose films with differe...

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Autores principales:	C. Fager, T. Gebäck, J. Hjärtstam, M. Röding, A. Olsson, N. Lorén, C. von Corswant, A. Särkkä, E. Olsson
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Focused ion beam Mass transport Scanning electron microscopy Polymer Soft material Three dimensional Chemical engineering TP155-156
Acceso en línea:	https://doaj.org/article/bc6a23434ea840498f6c212b22b16d61
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spelling	oai:doaj.org-article:bc6a23434ea840498f6c212b22b16d612021-11-26T04:39:05ZCorrelating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography2590-140010.1016/j.cesx.2021.100109https://doaj.org/article/bc6a23434ea840498f6c212b22b16d612021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590140021000228https://doaj.org/toc/2590-1400Porous polymer coatings are used to control drug release from pharmaceutical products. The coating covers a drug core and depending on the porous structure, different drug release rates are obtained. This work presents mass transport simulations performed on porous ethyl cellulose films with different porosities. The simulations were performed on high spatial resolution 3D data obtained using a focused ion beam scanning electron microscope. The effective diffusion coefficient of water was determined using a diffusion chamber. Lattice Boltzmann simulations were used to simulate water diffusion in the 3D data. The simulated coefficient was in good agreement with the measured coefficient. From the results it was concluded that the tortuosity and constrictivity of the porous network increase with decreasing amount of added hydroxypropyl cellulose, resulting in a sharp decrease in effective diffusion. This work shows that high spatial resolution 3D data is necessary, and that 2D data is insufficient, in order to predict diffusion through the porous structure with high accuracy.C. FagerT. GebäckJ. HjärtstamM. RödingA. OlssonN. LorénC. von CorswantA. SärkkäE. OlssonElsevierarticleFocused ion beamMass transportScanning electron microscopyPolymerSoft materialThree dimensionalChemical engineeringTP155-156ENChemical Engineering Science: X, Vol 12, Iss , Pp 100109- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Focused ion beam Mass transport Scanning electron microscopy Polymer Soft material Three dimensional Chemical engineering TP155-156
spellingShingle	Focused ion beam Mass transport Scanning electron microscopy Polymer Soft material Three dimensional Chemical engineering TP155-156 C. Fager T. Gebäck J. Hjärtstam M. Röding A. Olsson N. Lorén C. von Corswant A. Särkkä E. Olsson Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography
description	Porous polymer coatings are used to control drug release from pharmaceutical products. The coating covers a drug core and depending on the porous structure, different drug release rates are obtained. This work presents mass transport simulations performed on porous ethyl cellulose films with different porosities. The simulations were performed on high spatial resolution 3D data obtained using a focused ion beam scanning electron microscope. The effective diffusion coefficient of water was determined using a diffusion chamber. Lattice Boltzmann simulations were used to simulate water diffusion in the 3D data. The simulated coefficient was in good agreement with the measured coefficient. From the results it was concluded that the tortuosity and constrictivity of the porous network increase with decreasing amount of added hydroxypropyl cellulose, resulting in a sharp decrease in effective diffusion. This work shows that high spatial resolution 3D data is necessary, and that 2D data is insufficient, in order to predict diffusion through the porous structure with high accuracy.
format	article
author	C. Fager T. Gebäck J. Hjärtstam M. Röding A. Olsson N. Lorén C. von Corswant A. Särkkä E. Olsson
author_facet	C. Fager T. Gebäck J. Hjärtstam M. Röding A. Olsson N. Lorén C. von Corswant A. Särkkä E. Olsson
author_sort	C. Fager
title	Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography
title_short	Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography
title_full	Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography
title_fullStr	Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography
title_full_unstemmed	Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography
title_sort	correlating 3d porous structure in polymer films with mass transport properties using fib-sem tomography
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/bc6a23434ea840498f6c212b22b16d61
work_keys_str_mv	AT cfager correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography AT tgeback correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography AT jhjartstam correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography AT mroding correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography AT aolsson correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography AT nloren correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography AT cvoncorswant correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography AT asarkka correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography AT eolsson correlating3dporousstructureinpolymerfilmswithmasstransportpropertiesusingfibsemtomography
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Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography

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