An Antioxidant Enzyme Therapeutic for Sepsis

Sepsis is a systemic inflammatory response syndrome caused by infections that may lead to organ dysfunction with high mortality. With the rapid increase in the aging population and antimicrobial resistance, developing therapeutics for the treatment of sepsis has been an unmet medical need. Excessive...

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Autores principales:	Feifei Li, Ran Yan, Jun Wu, Zeren Han, Meng Qin, Chaoyong Liu, Yunfeng Lu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sepsis reactive oxygen species cytokines enzyme therepeutic catalase Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/bc6f35f026d44b6396fc89ffc8400523
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spelling	oai:doaj.org-article:bc6f35f026d44b6396fc89ffc84005232021-11-30T13:45:54ZAn Antioxidant Enzyme Therapeutic for Sepsis2296-418510.3389/fbioe.2021.800684https://doaj.org/article/bc6f35f026d44b6396fc89ffc84005232021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.800684/fullhttps://doaj.org/toc/2296-4185Sepsis is a systemic inflammatory response syndrome caused by infections that may lead to organ dysfunction with high mortality. With the rapid increase in the aging population and antimicrobial resistance, developing therapeutics for the treatment of sepsis has been an unmet medical need. Excessive production of reactive oxygen species (ROS) during inflammation is associated with the occurrence of sepsis. We report herein a treatment for sepsis based on PEGylated catalase, which can effectively break down hydrogen peroxide, a key component of ROS that is chemically stable and able to diffuse around the tissues and form downstream ROS. PEGylated catalase can effectively regulate the cytokine production by activated leukocytes, suppress the elevated level of AST, ALT, TNF-α, and IL-6 in mice with induced sepsis, and significantly improve the survival rate.Feifei LiFeifei LiRan YanJun WuZeren HanMeng QinMeng QinChaoyong LiuChaoyong LiuYunfeng LuFrontiers Media S.A.articlesepsisreactive oxygen speciescytokinesenzyme therepeuticcatalaseBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sepsis reactive oxygen species cytokines enzyme therepeutic catalase Biotechnology TP248.13-248.65
spellingShingle	sepsis reactive oxygen species cytokines enzyme therepeutic catalase Biotechnology TP248.13-248.65 Feifei Li Feifei Li Ran Yan Jun Wu Zeren Han Meng Qin Meng Qin Chaoyong Liu Chaoyong Liu Yunfeng Lu An Antioxidant Enzyme Therapeutic for Sepsis
description	Sepsis is a systemic inflammatory response syndrome caused by infections that may lead to organ dysfunction with high mortality. With the rapid increase in the aging population and antimicrobial resistance, developing therapeutics for the treatment of sepsis has been an unmet medical need. Excessive production of reactive oxygen species (ROS) during inflammation is associated with the occurrence of sepsis. We report herein a treatment for sepsis based on PEGylated catalase, which can effectively break down hydrogen peroxide, a key component of ROS that is chemically stable and able to diffuse around the tissues and form downstream ROS. PEGylated catalase can effectively regulate the cytokine production by activated leukocytes, suppress the elevated level of AST, ALT, TNF-α, and IL-6 in mice with induced sepsis, and significantly improve the survival rate.
format	article
author	Feifei Li Feifei Li Ran Yan Jun Wu Zeren Han Meng Qin Meng Qin Chaoyong Liu Chaoyong Liu Yunfeng Lu
author_facet	Feifei Li Feifei Li Ran Yan Jun Wu Zeren Han Meng Qin Meng Qin Chaoyong Liu Chaoyong Liu Yunfeng Lu
author_sort	Feifei Li
title	An Antioxidant Enzyme Therapeutic for Sepsis
title_short	An Antioxidant Enzyme Therapeutic for Sepsis
title_full	An Antioxidant Enzyme Therapeutic for Sepsis
title_fullStr	An Antioxidant Enzyme Therapeutic for Sepsis
title_full_unstemmed	An Antioxidant Enzyme Therapeutic for Sepsis
title_sort	antioxidant enzyme therapeutic for sepsis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bc6f35f026d44b6396fc89ffc8400523
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An Antioxidant Enzyme Therapeutic for Sepsis

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