Association between probiotics and bronchopulmonary dysplasia in preterm infants

Abstract Bronchopulmonary dysplasia is a chronic pulmonary disease with a high incidence in premature infants, and there is still no effective treatment. The purpose of our study was to analyze the association between the use of probiotics and BPD in premature infants. We retrospectively collected c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yangming Qu, Shijie Guo, Ying Liu, Guohua Wang, Hui Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc727ddf2d5d40e880bc8b6471721f04
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc727ddf2d5d40e880bc8b6471721f04
record_format	dspace
spelling	oai:doaj.org-article:bc727ddf2d5d40e880bc8b6471721f042021-12-02T16:34:53ZAssociation between probiotics and bronchopulmonary dysplasia in preterm infants10.1038/s41598-021-96489-z2045-2322https://doaj.org/article/bc727ddf2d5d40e880bc8b6471721f042021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96489-zhttps://doaj.org/toc/2045-2322Abstract Bronchopulmonary dysplasia is a chronic pulmonary disease with a high incidence in premature infants, and there is still no effective treatment. The purpose of our study was to analyze the association between the use of probiotics and BPD in premature infants. We retrospectively collected clinical data of infants with gestational age < 32 weeks admitted to the NICU of The First Hospital of Jilin University from January 1, 2019 to March 31, 2020. Demographic and clinicopathological data of the inclusion population were collected. The outcome was the incidence of BPD or death. The χ2 tests was used to compare the categorical variables. The t test and non-parametric Wilcoxon rank-sum test were used to compare the continuous data. Univariate and multivariate logistic regression were used to analyze the association between probiotics and BPD. A total of 318 newborns met the inclusion criteria, of which 94 received probiotics and 224 received no probiotics. There were 16 deaths and 115 newborns with BPD in the included population. The results of univariate analysis showed differences in the maternal diabetes, the proportion of systemic antibiotics given to mother within 24 h before birth, the receiving rate of invasive mechanical ventilation, the prevalence of BPD/death, PDA, RDS and Ivh between newborns with and without probiotics (p < 0.05); The results of unadjusted univariate logistic regression model showed that probiotic (OR 0.034, 95% CI 0.012–0.096) was the factor affecting BPD in preterm infants (p < 0.05). Multivariate logistic regression result (OR 0.037, 95% CI 0.013–0.105) was consistent with univariate analysis (P < 0.001). Probiotics are associated with a reduced risk of BPD in preterm infants < 32 weeks of age. More prospective studies with large samples are still needed.Yangming QuShijie GuoYing LiuGuohua WangHui WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yangming Qu Shijie Guo Ying Liu Guohua Wang Hui Wu Association between probiotics and bronchopulmonary dysplasia in preterm infants
description	Abstract Bronchopulmonary dysplasia is a chronic pulmonary disease with a high incidence in premature infants, and there is still no effective treatment. The purpose of our study was to analyze the association between the use of probiotics and BPD in premature infants. We retrospectively collected clinical data of infants with gestational age < 32 weeks admitted to the NICU of The First Hospital of Jilin University from January 1, 2019 to March 31, 2020. Demographic and clinicopathological data of the inclusion population were collected. The outcome was the incidence of BPD or death. The χ2 tests was used to compare the categorical variables. The t test and non-parametric Wilcoxon rank-sum test were used to compare the continuous data. Univariate and multivariate logistic regression were used to analyze the association between probiotics and BPD. A total of 318 newborns met the inclusion criteria, of which 94 received probiotics and 224 received no probiotics. There were 16 deaths and 115 newborns with BPD in the included population. The results of univariate analysis showed differences in the maternal diabetes, the proportion of systemic antibiotics given to mother within 24 h before birth, the receiving rate of invasive mechanical ventilation, the prevalence of BPD/death, PDA, RDS and Ivh between newborns with and without probiotics (p < 0.05); The results of unadjusted univariate logistic regression model showed that probiotic (OR 0.034, 95% CI 0.012–0.096) was the factor affecting BPD in preterm infants (p < 0.05). Multivariate logistic regression result (OR 0.037, 95% CI 0.013–0.105) was consistent with univariate analysis (P < 0.001). Probiotics are associated with a reduced risk of BPD in preterm infants < 32 weeks of age. More prospective studies with large samples are still needed.
format	article
author	Yangming Qu Shijie Guo Ying Liu Guohua Wang Hui Wu
author_facet	Yangming Qu Shijie Guo Ying Liu Guohua Wang Hui Wu
author_sort	Yangming Qu
title	Association between probiotics and bronchopulmonary dysplasia in preterm infants
title_short	Association between probiotics and bronchopulmonary dysplasia in preterm infants
title_full	Association between probiotics and bronchopulmonary dysplasia in preterm infants
title_fullStr	Association between probiotics and bronchopulmonary dysplasia in preterm infants
title_full_unstemmed	Association between probiotics and bronchopulmonary dysplasia in preterm infants
title_sort	association between probiotics and bronchopulmonary dysplasia in preterm infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc727ddf2d5d40e880bc8b6471721f04
work_keys_str_mv	AT yangmingqu associationbetweenprobioticsandbronchopulmonarydysplasiainpreterminfants AT shijieguo associationbetweenprobioticsandbronchopulmonarydysplasiainpreterminfants AT yingliu associationbetweenprobioticsandbronchopulmonarydysplasiainpreterminfants AT guohuawang associationbetweenprobioticsandbronchopulmonarydysplasiainpreterminfants AT huiwu associationbetweenprobioticsandbronchopulmonarydysplasiainpreterminfants
_version_	1718383777857667072

Association between probiotics and bronchopulmonary dysplasia in preterm infants

Ejemplares similares