Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.

<h4>Objectives</h4>Lung adenocarcinoma is considered a unique disease for Asian female non-smokers. We investigated whether plasma microRNA (miRNA) expression profiles are different by the EGFR status and are associated with survival outcomes of the patients.<h4>Methods</h4>U...

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Autores principales:	Huan Zhang, Yuliang Su, Fangxiu Xu, Jinyu Kong, Herbert Yu, Biyun Qian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc75975327204b49891c9a17dfb7d43e
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spelling	oai:doaj.org-article:bc75975327204b49891c9a17dfb7d43e2021-11-18T08:44:49ZCirculating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.1932-620310.1371/journal.pone.0081408https://doaj.org/article/bc75975327204b49891c9a17dfb7d43e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24282590/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Lung adenocarcinoma is considered a unique disease for Asian female non-smokers. We investigated whether plasma microRNA (miRNA) expression profiles are different by the EGFR status and are associated with survival outcomes of the patients.<h4>Methods</h4>Using real-time RT-PCR, we analyzed the expression of 20 miRNAs in the plasma of 105 female patients with lung adenocarcinoma. Kaplan-Meier survival analysis and Cox proportional hazards regression were performed to determine the association between miRNA expression and overall survival. Time dependent receiver operating characteristic (ROC) analysis was also performed.<h4>Results</h4>In the 20 miRNAs, miR-122 were found differently expressed between wild and mutant EGFR carriers (P=0.018). Advanced disease stage and tumor metastasis were independently associated with poor prognosis of patients with lung adenocarcinoma (P=0.010 and 1.0×10(-4)). Plasma levels of miR-195 and miR-122 expression were also associated with overall survival in the patients, especially in those with advanced stage (HR=0.23, 95%CI:0.07-0.84; and HR=0.22, 95%CI:0.06-0.77) and EGFR mutation (HR=0.27, 95%CI:0.08-0.96; and HR=0.23, 95%CI=0.06-0.81). Moreover, a model including miR-195, miR-122 may predict survival outcomes of female patients with lung adenocarcinoma (AUC=0.707).<h4>Conclusions</h4>Circulating miR-195 and miR-122 may have prognostic values in predicting the overall survival as well as predicting EGFR mutation status in non-smoking female patients with lung adenocarcinoma. Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma.Huan ZhangYuliang SuFangxiu XuJinyu KongHerbert YuBiyun QianPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81408 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huan Zhang Yuliang Su Fangxiu Xu Jinyu Kong Herbert Yu Biyun Qian Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.
description	<h4>Objectives</h4>Lung adenocarcinoma is considered a unique disease for Asian female non-smokers. We investigated whether plasma microRNA (miRNA) expression profiles are different by the EGFR status and are associated with survival outcomes of the patients.<h4>Methods</h4>Using real-time RT-PCR, we analyzed the expression of 20 miRNAs in the plasma of 105 female patients with lung adenocarcinoma. Kaplan-Meier survival analysis and Cox proportional hazards regression were performed to determine the association between miRNA expression and overall survival. Time dependent receiver operating characteristic (ROC) analysis was also performed.<h4>Results</h4>In the 20 miRNAs, miR-122 were found differently expressed between wild and mutant EGFR carriers (P=0.018). Advanced disease stage and tumor metastasis were independently associated with poor prognosis of patients with lung adenocarcinoma (P=0.010 and 1.0×10(-4)). Plasma levels of miR-195 and miR-122 expression were also associated with overall survival in the patients, especially in those with advanced stage (HR=0.23, 95%CI:0.07-0.84; and HR=0.22, 95%CI:0.06-0.77) and EGFR mutation (HR=0.27, 95%CI:0.08-0.96; and HR=0.23, 95%CI=0.06-0.81). Moreover, a model including miR-195, miR-122 may predict survival outcomes of female patients with lung adenocarcinoma (AUC=0.707).<h4>Conclusions</h4>Circulating miR-195 and miR-122 may have prognostic values in predicting the overall survival as well as predicting EGFR mutation status in non-smoking female patients with lung adenocarcinoma. Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma.
format	article
author	Huan Zhang Yuliang Su Fangxiu Xu Jinyu Kong Herbert Yu Biyun Qian
author_facet	Huan Zhang Yuliang Su Fangxiu Xu Jinyu Kong Herbert Yu Biyun Qian
author_sort	Huan Zhang
title	Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.
title_short	Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.
title_full	Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.
title_fullStr	Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.
title_full_unstemmed	Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.
title_sort	circulating micrornas in relation to egfr status and survival of lung adenocarcinoma in female non-smokers.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/bc75975327204b49891c9a17dfb7d43e
work_keys_str_mv	AT huanzhang circulatingmicrornasinrelationtoegfrstatusandsurvivaloflungadenocarcinomainfemalenonsmokers AT yuliangsu circulatingmicrornasinrelationtoegfrstatusandsurvivaloflungadenocarcinomainfemalenonsmokers AT fangxiuxu circulatingmicrornasinrelationtoegfrstatusandsurvivaloflungadenocarcinomainfemalenonsmokers AT jinyukong circulatingmicrornasinrelationtoegfrstatusandsurvivaloflungadenocarcinomainfemalenonsmokers AT herbertyu circulatingmicrornasinrelationtoegfrstatusandsurvivaloflungadenocarcinomainfemalenonsmokers AT biyunqian circulatingmicrornasinrelationtoegfrstatusandsurvivaloflungadenocarcinomainfemalenonsmokers
_version_	1718421406497112064

Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.

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