The Effect of Agarose on 3D Bioprinting

In three-dimensional (3D) bioprinting, the accuracy, stability, and mechanical properties of the formed structure are very important to the overall composition and internal structure of the complex organ. In traditional 3D bioprinting, low-temperature gelatinization of gelatin is often used to const...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chi Gong, Zhiyuan Kong, Xiaohong Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	3D bioprinting agarose pregelatinization organ manufacturing Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/bc75f306ee5f48a38fd8a30a7f9d0b37
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc75f306ee5f48a38fd8a30a7f9d0b37
record_format	dspace
spelling	oai:doaj.org-article:bc75f306ee5f48a38fd8a30a7f9d0b372021-11-25T18:49:31ZThe Effect of Agarose on 3D Bioprinting10.3390/polym132240282073-4360https://doaj.org/article/bc75f306ee5f48a38fd8a30a7f9d0b372021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/4028https://doaj.org/toc/2073-4360In three-dimensional (3D) bioprinting, the accuracy, stability, and mechanical properties of the formed structure are very important to the overall composition and internal structure of the complex organ. In traditional 3D bioprinting, low-temperature gelatinization of gelatin is often used to construct complex tissues and organs. However, the hydrosol relies too much on the concentration of gelatin and has limited formation accuracy and stability. In this study, we take advantage of the physical crosslinking of agarose at 35–40 °C to replace the single pregelatinization effect of gelatin in 3D bioprinting, and printing composite gelatin/alginate/agarose hydrogels at two temperatures, i.e., 10 °C and 24 °C, respectively. After in-depth research, we find that the structures manufactured by the pregelatinization method of agarose are significantly more accurate, more stable, and harder than those pregelatined by gelatin. We believe that this research holds the potential to be widely used in the future organ manufacturing fields with high structural accuracy and stability.Chi GongZhiyuan KongXiaohong WangMDPI AGarticle3D bioprintingagarosepregelatinizationorgan manufacturingOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 4028, p 4028 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D bioprinting agarose pregelatinization organ manufacturing Organic chemistry QD241-441
spellingShingle	3D bioprinting agarose pregelatinization organ manufacturing Organic chemistry QD241-441 Chi Gong Zhiyuan Kong Xiaohong Wang The Effect of Agarose on 3D Bioprinting
description	In three-dimensional (3D) bioprinting, the accuracy, stability, and mechanical properties of the formed structure are very important to the overall composition and internal structure of the complex organ. In traditional 3D bioprinting, low-temperature gelatinization of gelatin is often used to construct complex tissues and organs. However, the hydrosol relies too much on the concentration of gelatin and has limited formation accuracy and stability. In this study, we take advantage of the physical crosslinking of agarose at 35–40 °C to replace the single pregelatinization effect of gelatin in 3D bioprinting, and printing composite gelatin/alginate/agarose hydrogels at two temperatures, i.e., 10 °C and 24 °C, respectively. After in-depth research, we find that the structures manufactured by the pregelatinization method of agarose are significantly more accurate, more stable, and harder than those pregelatined by gelatin. We believe that this research holds the potential to be widely used in the future organ manufacturing fields with high structural accuracy and stability.
format	article
author	Chi Gong Zhiyuan Kong Xiaohong Wang
author_facet	Chi Gong Zhiyuan Kong Xiaohong Wang
author_sort	Chi Gong
title	The Effect of Agarose on 3D Bioprinting
title_short	The Effect of Agarose on 3D Bioprinting
title_full	The Effect of Agarose on 3D Bioprinting
title_fullStr	The Effect of Agarose on 3D Bioprinting
title_full_unstemmed	The Effect of Agarose on 3D Bioprinting
title_sort	effect of agarose on 3d bioprinting
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bc75f306ee5f48a38fd8a30a7f9d0b37
work_keys_str_mv	AT chigong theeffectofagaroseon3dbioprinting AT zhiyuankong theeffectofagaroseon3dbioprinting AT xiaohongwang theeffectofagaroseon3dbioprinting AT chigong effectofagaroseon3dbioprinting AT zhiyuankong effectofagaroseon3dbioprinting AT xiaohongwang effectofagaroseon3dbioprinting
_version_	1718410673003692032

The Effect of Agarose on 3D Bioprinting

Ejemplares similares