Transient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report

Sara Elhadari, Mahir Hamad Acute Medicine Department, The James Cook University Hospital, Middlesbrough, TS4 3BW, UKCorrespondence: Sara Elhadari Email sara.elhadari@nhs.netAbstract: A 67-year-old Caucasian female presented in August 2019 to our rheumatology service, with 3 days history of severe ne...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elhadari S, Hamad M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	egpa anca vasculitis churg strauss syndrome eosinophilia anti ige antibodies. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/bc764b0fe48f44ec9c1748cc7f895660
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc764b0fe48f44ec9c1748cc7f895660
record_format	dspace
spelling	oai:doaj.org-article:bc764b0fe48f44ec9c1748cc7f8956602021-12-02T10:08:49ZTransient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report1179-156Xhttps://doaj.org/article/bc764b0fe48f44ec9c1748cc7f8956602020-07-01T00:00:00Zhttps://www.dovepress.com/transient-eosinophilic-granulomatosis-with-polyangiitis-like-vasculiti-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XSara Elhadari, Mahir Hamad Acute Medicine Department, The James Cook University Hospital, Middlesbrough, TS4 3BW, UKCorrespondence: Sara Elhadari Email sara.elhadari@nhs.netAbstract: A 67-year-old Caucasian female presented in August 2019 to our rheumatology service, with 3 days history of severe neck pain and right-sided headache with aches in both shoulders and arms and mild stiffness. Other symptoms included mild jaw claudication. She had recently returned from Majorca after an uneventful two-week trip. She had a background of severe allergic asthma and allergic rhinitis, well controlled with omalizumab which was started in 2016, based on persistently high IgE. Her sister suffers from a type of vasculitis and is currently on steroids. The patient is an ex-smoker and drinks two bottles of wine a week. She had high inflammatory markers with raised eosinophilic count and was admitted for further work up to rule out infection and to commence steroid after for a likely diagnosis of eosinophilic granulomatosis with polyangiitis. Shortly after admission to the acute assessment unit, she became confused and febrile. An extensive work up ruled out infection, and she was started on steroids and treated for acute hyponatremia. Omalizumab was stopped. She improved and was discharged on a tapering dose of steroids and was weaned off completely within 4 months. Her inflammatory markers returned to normal as well as her eosinophilic count, with complete resolution of her presenting symptoms.Keywords: EGPA, ANCA, vasculitis, Churg-Strauss syndrome, eosinophilia, anti-IgE antibodiesElhadari SHamad MDove Medical Pressarticleegpaancavasculitischurg strauss syndromeeosinophiliaanti ige antibodies.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 127-131 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	egpa anca vasculitis churg strauss syndrome eosinophilia anti ige antibodies. Diseases of the musculoskeletal system RC925-935
spellingShingle	egpa anca vasculitis churg strauss syndrome eosinophilia anti ige antibodies. Diseases of the musculoskeletal system RC925-935 Elhadari S Hamad M Transient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report
description	Sara Elhadari, Mahir Hamad Acute Medicine Department, The James Cook University Hospital, Middlesbrough, TS4 3BW, UKCorrespondence: Sara Elhadari Email sara.elhadari@nhs.netAbstract: A 67-year-old Caucasian female presented in August 2019 to our rheumatology service, with 3 days history of severe neck pain and right-sided headache with aches in both shoulders and arms and mild stiffness. Other symptoms included mild jaw claudication. She had recently returned from Majorca after an uneventful two-week trip. She had a background of severe allergic asthma and allergic rhinitis, well controlled with omalizumab which was started in 2016, based on persistently high IgE. Her sister suffers from a type of vasculitis and is currently on steroids. The patient is an ex-smoker and drinks two bottles of wine a week. She had high inflammatory markers with raised eosinophilic count and was admitted for further work up to rule out infection and to commence steroid after for a likely diagnosis of eosinophilic granulomatosis with polyangiitis. Shortly after admission to the acute assessment unit, she became confused and febrile. An extensive work up ruled out infection, and she was started on steroids and treated for acute hyponatremia. Omalizumab was stopped. She improved and was discharged on a tapering dose of steroids and was weaned off completely within 4 months. Her inflammatory markers returned to normal as well as her eosinophilic count, with complete resolution of her presenting symptoms.Keywords: EGPA, ANCA, vasculitis, Churg-Strauss syndrome, eosinophilia, anti-IgE antibodies
format	article
author	Elhadari S Hamad M
author_facet	Elhadari S Hamad M
author_sort	Elhadari S
title	Transient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report
title_short	Transient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report
title_full	Transient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report
title_fullStr	Transient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report
title_full_unstemmed	Transient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report
title_sort	transient eosinophilic granulomatosis with polyangiitis-like vasculitis during omalizumab therapy: a case report
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bc764b0fe48f44ec9c1748cc7f895660
work_keys_str_mv	AT elhadaris transienteosinophilicgranulomatosiswithpolyangiitislikevasculitisduringomalizumabtherapyacasereport AT hamadm transienteosinophilicgranulomatosiswithpolyangiitislikevasculitisduringomalizumabtherapyacasereport
_version_	1718397595824422912

Transient Eosinophilic Granulomatosis with Polyangiitis-Like Vasculitis During Omalizumab Therapy: A Case Report

Ejemplares similares