Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly

The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin filaments mechano-inhibits Cdc12-mediated assembly, w...

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Autores principales:	Dennis Zimmermann, Kaitlin E. Homa, Glen M. Hocky, Luther W. Pollard, Enrique M. De La Cruz, Gregory A. Voth, Kathleen M. Trybus, David R. Kovar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc76ecd9ae8c4d8a8269a508fded3c34
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spelling	oai:doaj.org-article:bc76ecd9ae8c4d8a8269a508fded3c342021-12-02T15:38:31ZMechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly10.1038/s41467-017-00445-32041-1723https://doaj.org/article/bc76ecd9ae8c4d8a8269a508fded3c342017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00445-3https://doaj.org/toc/2041-1723The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin filaments mechano-inhibits Cdc12-mediated assembly, which enables proper ring assembly in vivo.Dennis ZimmermannKaitlin E. HomaGlen M. HockyLuther W. PollardEnrique M. De La CruzGregory A. VothKathleen M. TrybusDavid R. KovarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dennis Zimmermann Kaitlin E. Homa Glen M. Hocky Luther W. Pollard Enrique M. De La Cruz Gregory A. Voth Kathleen M. Trybus David R. Kovar Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
description	The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin filaments mechano-inhibits Cdc12-mediated assembly, which enables proper ring assembly in vivo.
format	article
author	Dennis Zimmermann Kaitlin E. Homa Glen M. Hocky Luther W. Pollard Enrique M. De La Cruz Gregory A. Voth Kathleen M. Trybus David R. Kovar
author_facet	Dennis Zimmermann Kaitlin E. Homa Glen M. Hocky Luther W. Pollard Enrique M. De La Cruz Gregory A. Voth Kathleen M. Trybus David R. Kovar
author_sort	Dennis Zimmermann
title	Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
title_short	Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
title_full	Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
title_fullStr	Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
title_full_unstemmed	Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
title_sort	mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bc76ecd9ae8c4d8a8269a508fded3c34
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_version_	1718386197957443584

Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly

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