BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.

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Autores principales:	Kajal Biswas, Subha Philip, Aditya Yadav, Betty K. Martin, Sandra Burkett, Vaibhav Singh, Anav Babbar, Susan Lynn North, Suhwan Chang, Shyam K. Sharan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc7b43181d7c4b239e3ec26ecbcf70ca
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spelling	oai:doaj.org-article:bc7b43181d7c4b239e3ec26ecbcf70ca2021-12-02T16:49:23ZBRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage10.1038/s41467-018-03020-62041-1723https://doaj.org/article/bc7b43181d7c4b239e3ec26ecbcf70ca2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03020-6https://doaj.org/toc/2041-1723Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.Kajal BiswasSubha PhilipAditya YadavBetty K. MartinSandra BurkettVaibhav SinghAnav BabbarSusan Lynn NorthSuhwan ChangShyam K. SharanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kajal Biswas Subha Philip Aditya Yadav Betty K. Martin Sandra Burkett Vaibhav Singh Anav Babbar Susan Lynn North Suhwan Chang Shyam K. Sharan BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
description	Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.
format	article
author	Kajal Biswas Subha Philip Aditya Yadav Betty K. Martin Sandra Burkett Vaibhav Singh Anav Babbar Susan Lynn North Suhwan Chang Shyam K. Sharan
author_facet	Kajal Biswas Subha Philip Aditya Yadav Betty K. Martin Sandra Burkett Vaibhav Singh Anav Babbar Susan Lynn North Suhwan Chang Shyam K. Sharan
author_sort	Kajal Biswas
title	BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
title_short	BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
title_full	BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
title_fullStr	BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
title_full_unstemmed	BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
title_sort	bre/brcc45 regulates cdc25a stability by recruiting usp7 in response to dna damage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bc7b43181d7c4b239e3ec26ecbcf70ca
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BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

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