BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.

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Autores principales: Kajal Biswas, Subha Philip, Aditya Yadav, Betty K. Martin, Sandra Burkett, Vaibhav Singh, Anav Babbar, Susan Lynn North, Suhwan Chang, Shyam K. Sharan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/bc7b43181d7c4b239e3ec26ecbcf70ca
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