Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America
Abstract Circulating recombinant forms (CRFs) contribute substantially to the HIV-1 pandemic. Among 105 CRFs described in the literature, 16 are BF intersubtype recombinants, most of South American origin, of which CRF12_BF is the most widely spread. A BF recombinant cluster identified in Bolivia wa...
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2021
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oai:doaj.org-article:bc7dcde9066b465f828a631ef67448d82021-12-02T17:51:21ZIdentification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America10.1038/s41598-021-90023-x2045-2322https://doaj.org/article/bc7dcde9066b465f828a631ef67448d82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90023-xhttps://doaj.org/toc/2045-2322Abstract Circulating recombinant forms (CRFs) contribute substantially to the HIV-1 pandemic. Among 105 CRFs described in the literature, 16 are BF intersubtype recombinants, most of South American origin, of which CRF12_BF is the most widely spread. A BF recombinant cluster identified in Bolivia was suggested to represent a new CRF_BF. Here we find that it belongs to a larger cluster incorporating 39 viruses collected in 7 countries from 3 continents, 22 of them in Spain, most from Bolivian or Peruvian individuals, and 12 in South America (Bolivia, Argentina, and Peru). This BF cluster comprises three major subclusters, two associated with Bolivian and one with Peruvian individuals. Near full-length genome sequence analyses of nine viruses, collected in Spain, Bolivia, and Peru, revealed coincident BF mosaic structures, with 13 breakpoints, 6 and 7 of which coincided with CRF12_BF and CRF17_BF, respectively. In a phylogenetic tree, they grouped in a clade closely related to these CRFs, and more distantly to CRF38_BF and CRF44_BF, all circulating in South America. These results allowed to identify a new HIV-1 CRF, designated CRF89_BF. Through phylodynamic analyses, CRF89_BF emergence was estimated in Bolivia around 1986. CRF89_BF is the fifth CRF member of the HIV-1 recombinant family related to CRF12_BF.Elena DelgadoAurora Fernández-GarcíaMarcos Pérez-LosadaMaría Moreno-LorenzoIsmael Fernández-MirandaSonia BenitoVanessa MonteroHoracio GilSilvia HernáezJosefa MuñozMiren Z. Zubero-SulibarriaElena García-BodasMónica SánchezJorge del RomeroCarmen RodríguezLuis ElorduyElena BereciartuaEsther CulebrasIcíar Rodríguez-AvialMaría Luisa Giménez-AlarcónCarmen Martín-SalasCarmen Gómez-GonzálezJosé J. García-IrureGema CenzualAna Martínez-SapiñaMaría Maiques-CamareroLucía Pérez-ÁlvarezMichael M. ThomsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
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Medicine R Science Q Elena Delgado Aurora Fernández-García Marcos Pérez-Losada María Moreno-Lorenzo Ismael Fernández-Miranda Sonia Benito Vanessa Montero Horacio Gil Silvia Hernáez Josefa Muñoz Miren Z. Zubero-Sulibarria Elena García-Bodas Mónica Sánchez Jorge del Romero Carmen Rodríguez Luis Elorduy Elena Bereciartua Esther Culebras Icíar Rodríguez-Avial María Luisa Giménez-Alarcón Carmen Martín-Salas Carmen Gómez-González José J. García-Irure Gema Cenzual Ana Martínez-Sapiña María Maiques-Camarero Lucía Pérez-Álvarez Michael M. Thomson Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America |
| description |
Abstract Circulating recombinant forms (CRFs) contribute substantially to the HIV-1 pandemic. Among 105 CRFs described in the literature, 16 are BF intersubtype recombinants, most of South American origin, of which CRF12_BF is the most widely spread. A BF recombinant cluster identified in Bolivia was suggested to represent a new CRF_BF. Here we find that it belongs to a larger cluster incorporating 39 viruses collected in 7 countries from 3 continents, 22 of them in Spain, most from Bolivian or Peruvian individuals, and 12 in South America (Bolivia, Argentina, and Peru). This BF cluster comprises three major subclusters, two associated with Bolivian and one with Peruvian individuals. Near full-length genome sequence analyses of nine viruses, collected in Spain, Bolivia, and Peru, revealed coincident BF mosaic structures, with 13 breakpoints, 6 and 7 of which coincided with CRF12_BF and CRF17_BF, respectively. In a phylogenetic tree, they grouped in a clade closely related to these CRFs, and more distantly to CRF38_BF and CRF44_BF, all circulating in South America. These results allowed to identify a new HIV-1 CRF, designated CRF89_BF. Through phylodynamic analyses, CRF89_BF emergence was estimated in Bolivia around 1986. CRF89_BF is the fifth CRF member of the HIV-1 recombinant family related to CRF12_BF. |
| format |
article |
| author |
Elena Delgado Aurora Fernández-García Marcos Pérez-Losada María Moreno-Lorenzo Ismael Fernández-Miranda Sonia Benito Vanessa Montero Horacio Gil Silvia Hernáez Josefa Muñoz Miren Z. Zubero-Sulibarria Elena García-Bodas Mónica Sánchez Jorge del Romero Carmen Rodríguez Luis Elorduy Elena Bereciartua Esther Culebras Icíar Rodríguez-Avial María Luisa Giménez-Alarcón Carmen Martín-Salas Carmen Gómez-González José J. García-Irure Gema Cenzual Ana Martínez-Sapiña María Maiques-Camarero Lucía Pérez-Álvarez Michael M. Thomson |
| author_facet |
Elena Delgado Aurora Fernández-García Marcos Pérez-Losada María Moreno-Lorenzo Ismael Fernández-Miranda Sonia Benito Vanessa Montero Horacio Gil Silvia Hernáez Josefa Muñoz Miren Z. Zubero-Sulibarria Elena García-Bodas Mónica Sánchez Jorge del Romero Carmen Rodríguez Luis Elorduy Elena Bereciartua Esther Culebras Icíar Rodríguez-Avial María Luisa Giménez-Alarcón Carmen Martín-Salas Carmen Gómez-González José J. García-Irure Gema Cenzual Ana Martínez-Sapiña María Maiques-Camarero Lucía Pérez-Álvarez Michael M. Thomson |
| author_sort |
Elena Delgado |
| title |
Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America |
| title_short |
Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America |
| title_full |
Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America |
| title_fullStr |
Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America |
| title_full_unstemmed |
Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America |
| title_sort |
identification of crf89_bf, a new member of an hiv-1 circulating bf intersubtype recombinant form family widely spread in south america |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/bc7dcde9066b465f828a631ef67448d8 |
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