Large-scale resculpting of cortical circuits in children after surgical resection

Abstract Despite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolesc...

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Autores principales:	Anne Margarette S. Maallo, Michael C. Granovetter, Erez Freud, Sabine Kastner, Mark A. Pinsk, Christina Patterson, Marlene Behrmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc7e74486200431aac88ac142eda9cdb
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spelling	oai:doaj.org-article:bc7e74486200431aac88ac142eda9cdb2021-12-02T12:33:14ZLarge-scale resculpting of cortical circuits in children after surgical resection10.1038/s41598-020-78394-z2045-2322https://doaj.org/article/bc7e74486200431aac88ac142eda9cdb2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78394-zhttps://doaj.org/toc/2045-2322Abstract Despite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection.Anne Margarette S. MaalloMichael C. GranovetterErez FreudSabine KastnerMark A. PinskChristina PattersonMarlene BehrmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne Margarette S. Maallo Michael C. Granovetter Erez Freud Sabine Kastner Mark A. Pinsk Christina Patterson Marlene Behrmann Large-scale resculpting of cortical circuits in children after surgical resection
description	Abstract Despite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection.
format	article
author	Anne Margarette S. Maallo Michael C. Granovetter Erez Freud Sabine Kastner Mark A. Pinsk Christina Patterson Marlene Behrmann
author_facet	Anne Margarette S. Maallo Michael C. Granovetter Erez Freud Sabine Kastner Mark A. Pinsk Christina Patterson Marlene Behrmann
author_sort	Anne Margarette S. Maallo
title	Large-scale resculpting of cortical circuits in children after surgical resection
title_short	Large-scale resculpting of cortical circuits in children after surgical resection
title_full	Large-scale resculpting of cortical circuits in children after surgical resection
title_fullStr	Large-scale resculpting of cortical circuits in children after surgical resection
title_full_unstemmed	Large-scale resculpting of cortical circuits in children after surgical resection
title_sort	large-scale resculpting of cortical circuits in children after surgical resection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bc7e74486200431aac88ac142eda9cdb
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Large-scale resculpting of cortical circuits in children after surgical resection

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