Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis

The transcriptional regulation of murine spermatogenesis is not well understood. Here, the authors use single-cell and bulk RNA-Sequencing of juvenile and adult mice to characterise somatic and germ cell development, and chromatin profile the X chromosome to show that spermatid-specific genes are re...

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Autores principales:	Christina Ernst, Nils Eling, Celia P. Martinez-Jimenez, John C. Marioni, Duncan T. Odom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc7e9055ff6e43a8ad2daf0f91f1d334
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spelling	oai:doaj.org-article:bc7e9055ff6e43a8ad2daf0f91f1d3342021-12-02T17:01:50ZStaged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis10.1038/s41467-019-09182-12041-1723https://doaj.org/article/bc7e9055ff6e43a8ad2daf0f91f1d3342019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09182-1https://doaj.org/toc/2041-1723The transcriptional regulation of murine spermatogenesis is not well understood. Here, the authors use single-cell and bulk RNA-Sequencing of juvenile and adult mice to characterise somatic and germ cell development, and chromatin profile the X chromosome to show that spermatid-specific genes are repressed by H3K9me3 during meiosis.Christina ErnstNils ElingCelia P. Martinez-JimenezJohn C. MarioniDuncan T. OdomNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christina Ernst Nils Eling Celia P. Martinez-Jimenez John C. Marioni Duncan T. Odom Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
description	The transcriptional regulation of murine spermatogenesis is not well understood. Here, the authors use single-cell and bulk RNA-Sequencing of juvenile and adult mice to characterise somatic and germ cell development, and chromatin profile the X chromosome to show that spermatid-specific genes are repressed by H3K9me3 during meiosis.
format	article
author	Christina Ernst Nils Eling Celia P. Martinez-Jimenez John C. Marioni Duncan T. Odom
author_facet	Christina Ernst Nils Eling Celia P. Martinez-Jimenez John C. Marioni Duncan T. Odom
author_sort	Christina Ernst
title	Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
title_short	Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
title_full	Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
title_fullStr	Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
title_full_unstemmed	Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
title_sort	staged developmental mapping and x chromosome transcriptional dynamics during mouse spermatogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bc7e9055ff6e43a8ad2daf0f91f1d334
work_keys_str_mv	AT christinaernst stageddevelopmentalmappingandxchromosometranscriptionaldynamicsduringmousespermatogenesis AT nilseling stageddevelopmentalmappingandxchromosometranscriptionaldynamicsduringmousespermatogenesis AT celiapmartinezjimenez stageddevelopmentalmappingandxchromosometranscriptionaldynamicsduringmousespermatogenesis AT johncmarioni stageddevelopmentalmappingandxchromosometranscriptionaldynamicsduringmousespermatogenesis AT duncantodom stageddevelopmentalmappingandxchromosometranscriptionaldynamicsduringmousespermatogenesis
_version_	1718382048799883264

Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis

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