Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic

Abstract Understanding the diversity and circulation dynamics of seasonal influenza viruses is key to public health decision-making. The limited genetic information of pre-pandemic seasonal IAVs in Chile has made it difficult to accurately reconstruct the phylogenetic relationships of these viruses...

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Autores principales:	Juan Mena, Rodrigo Tapia, Claudio Verdugo, Luis Avendaño, Paulina Parra-Castro, Rafael A. Medina, Gonzalo Barriga, Víctor Neira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc7ecfd5ad22423588144bae8992435c
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spelling	oai:doaj.org-article:bc7ecfd5ad22423588144bae8992435c2021-11-08T10:55:27ZCirculation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic10.1038/s41598-021-00795-52045-2322https://doaj.org/article/bc7ecfd5ad22423588144bae8992435c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00795-5https://doaj.org/toc/2045-2322Abstract Understanding the diversity and circulation dynamics of seasonal influenza viruses is key to public health decision-making. The limited genetic information of pre-pandemic seasonal IAVs in Chile has made it difficult to accurately reconstruct the phylogenetic relationships of these viruses within the country. The objective of this study was to determine the genetic diversity of pre-pandemic human seasonal IAVs in Chile. We sequenced the complete genome of 42 historic IAV obtained between 1996 and 2007. The phylogeny was determined using HA sequences and complemented using other segments. Time-scale phylogenetic analyses revealed that the diversity of pre-pandemic human seasonal IAVs in Chile was influenced by continuous introductions of new A/H1N1 and A/H3N2 lineages and constant viral exchange between Chile and other countries every year. These results provide important knowledge about genetic diversity and evolutionary patterns of pre-pandemic human seasonal IAVs in Chile, which can help design optimal surveillance systems and prevention strategies. However, future studies with current sequences should be conducted.Juan MenaRodrigo TapiaClaudio VerdugoLuis AvendañoPaulina Parra-CastroRafael A. MedinaGonzalo BarrigaVíctor NeiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Mena Rodrigo Tapia Claudio Verdugo Luis Avendaño Paulina Parra-Castro Rafael A. Medina Gonzalo Barriga Víctor Neira Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic
description	Abstract Understanding the diversity and circulation dynamics of seasonal influenza viruses is key to public health decision-making. The limited genetic information of pre-pandemic seasonal IAVs in Chile has made it difficult to accurately reconstruct the phylogenetic relationships of these viruses within the country. The objective of this study was to determine the genetic diversity of pre-pandemic human seasonal IAVs in Chile. We sequenced the complete genome of 42 historic IAV obtained between 1996 and 2007. The phylogeny was determined using HA sequences and complemented using other segments. Time-scale phylogenetic analyses revealed that the diversity of pre-pandemic human seasonal IAVs in Chile was influenced by continuous introductions of new A/H1N1 and A/H3N2 lineages and constant viral exchange between Chile and other countries every year. These results provide important knowledge about genetic diversity and evolutionary patterns of pre-pandemic human seasonal IAVs in Chile, which can help design optimal surveillance systems and prevention strategies. However, future studies with current sequences should be conducted.
format	article
author	Juan Mena Rodrigo Tapia Claudio Verdugo Luis Avendaño Paulina Parra-Castro Rafael A. Medina Gonzalo Barriga Víctor Neira
author_facet	Juan Mena Rodrigo Tapia Claudio Verdugo Luis Avendaño Paulina Parra-Castro Rafael A. Medina Gonzalo Barriga Víctor Neira
author_sort	Juan Mena
title	Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic
title_short	Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic
title_full	Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic
title_fullStr	Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic
title_full_unstemmed	Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic
title_sort	circulation patterns of human seasonal influenza a viruses in chile before h1n1pdm09 pandemic
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc7ecfd5ad22423588144bae8992435c
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Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic

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