Immunomodulatory Effects of Nanoparticles on Skin Allergy

Abstract In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samreen Jatana, Brian C. Palmer, Sarah J. Phelan, Lisa A. DeLouise
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc8d383934394039b23a18df34256048
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc8d383934394039b23a18df34256048
record_format	dspace
spelling	oai:doaj.org-article:bc8d383934394039b23a18df342560482021-12-02T12:32:37ZImmunomodulatory Effects of Nanoparticles on Skin Allergy10.1038/s41598-017-03729-22045-2322https://doaj.org/article/bc8d383934394039b23a18df342560482017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03729-2https://doaj.org/toc/2045-2322Abstract In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety of NPs that vary in size, charge and composition. Results show that small (<200 nm) negative and neutral charged NPs exhibit an immunosuppressive effect but that positively charged NPs do not. Confocal imaging suggests positively charged NPs may penetrate skin to a lesser extent and thereby are less able interact with and alter the local immune responses. Interestingly, negatively charged silica (20 nm) NPs suppress allergic response to two chemically distinct sensitizers; 1-fluoro-2, 4-dinitrobenzene and 2-deoxyurushiol. Skin wiping and NP application time studies suggest that the immunomodulatory mechanism is not due solely to the blocking of sensitizer adduct formation in skin. Results suggest that NPs modulate early immune events that impact mast cell degranulation. Our study shows for the first time the potential to modulate the elicitation phase of the allergic response which depends on the NP charge and composition. These finding can be used to inform the design topical therapeutics to mitigate allergic responses in skin.Samreen JatanaBrian C. PalmerSarah J. PhelanLisa A. DeLouiseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samreen Jatana Brian C. Palmer Sarah J. Phelan Lisa A. DeLouise Immunomodulatory Effects of Nanoparticles on Skin Allergy
description	Abstract In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety of NPs that vary in size, charge and composition. Results show that small (<200 nm) negative and neutral charged NPs exhibit an immunosuppressive effect but that positively charged NPs do not. Confocal imaging suggests positively charged NPs may penetrate skin to a lesser extent and thereby are less able interact with and alter the local immune responses. Interestingly, negatively charged silica (20 nm) NPs suppress allergic response to two chemically distinct sensitizers; 1-fluoro-2, 4-dinitrobenzene and 2-deoxyurushiol. Skin wiping and NP application time studies suggest that the immunomodulatory mechanism is not due solely to the blocking of sensitizer adduct formation in skin. Results suggest that NPs modulate early immune events that impact mast cell degranulation. Our study shows for the first time the potential to modulate the elicitation phase of the allergic response which depends on the NP charge and composition. These finding can be used to inform the design topical therapeutics to mitigate allergic responses in skin.
format	article
author	Samreen Jatana Brian C. Palmer Sarah J. Phelan Lisa A. DeLouise
author_facet	Samreen Jatana Brian C. Palmer Sarah J. Phelan Lisa A. DeLouise
author_sort	Samreen Jatana
title	Immunomodulatory Effects of Nanoparticles on Skin Allergy
title_short	Immunomodulatory Effects of Nanoparticles on Skin Allergy
title_full	Immunomodulatory Effects of Nanoparticles on Skin Allergy
title_fullStr	Immunomodulatory Effects of Nanoparticles on Skin Allergy
title_full_unstemmed	Immunomodulatory Effects of Nanoparticles on Skin Allergy
title_sort	immunomodulatory effects of nanoparticles on skin allergy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bc8d383934394039b23a18df34256048
work_keys_str_mv	AT samreenjatana immunomodulatoryeffectsofnanoparticlesonskinallergy AT briancpalmer immunomodulatoryeffectsofnanoparticlesonskinallergy AT sarahjphelan immunomodulatoryeffectsofnanoparticlesonskinallergy AT lisaadelouise immunomodulatoryeffectsofnanoparticlesonskinallergy
_version_	1718394059477745664

Immunomodulatory Effects of Nanoparticles on Skin Allergy

Ejemplares similares