Identifying therapeutic drug targets using bidirectional effect genes

Prioritising genes as potential drug targets is challenging and often unsuccessful once testing efficacy in humans. Here, the authors propose an approach to identifying drug targets that uses evidence from gain- or loss-of-function mutations associated with bidirectional effects on phenotypes.

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Detalles Bibliográficos
Autores principales:	Karol Estrada, Steven Froelich, Arthur Wuster, Christopher R. Bauer, Teague Sterling, Wyatt T. Clark, Yuanbin Ru, Marena Trinidad, Hong Phuc Nguyen, Amanda R. Luu, Daniel J. Wendt, Gouri Yogalingam, Guoying Karen Yu, Jonathan H. LeBowitz, Lon R. Cardon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc9abc10fee1429d8bd83e6241883e5f
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spelling	oai:doaj.org-article:bc9abc10fee1429d8bd83e6241883e5f2021-12-02T18:02:47ZIdentifying therapeutic drug targets using bidirectional effect genes10.1038/s41467-021-21843-82041-1723https://doaj.org/article/bc9abc10fee1429d8bd83e6241883e5f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21843-8https://doaj.org/toc/2041-1723Prioritising genes as potential drug targets is challenging and often unsuccessful once testing efficacy in humans. Here, the authors propose an approach to identifying drug targets that uses evidence from gain- or loss-of-function mutations associated with bidirectional effects on phenotypes.Karol EstradaSteven FroelichArthur WusterChristopher R. BauerTeague SterlingWyatt T. ClarkYuanbin RuMarena TrinidadHong Phuc NguyenAmanda R. LuuDaniel J. WendtGouri YogalingamGuoying Karen YuJonathan H. LeBowitzLon R. CardonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karol Estrada Steven Froelich Arthur Wuster Christopher R. Bauer Teague Sterling Wyatt T. Clark Yuanbin Ru Marena Trinidad Hong Phuc Nguyen Amanda R. Luu Daniel J. Wendt Gouri Yogalingam Guoying Karen Yu Jonathan H. LeBowitz Lon R. Cardon Identifying therapeutic drug targets using bidirectional effect genes
description	Prioritising genes as potential drug targets is challenging and often unsuccessful once testing efficacy in humans. Here, the authors propose an approach to identifying drug targets that uses evidence from gain- or loss-of-function mutations associated with bidirectional effects on phenotypes.
format	article
author	Karol Estrada Steven Froelich Arthur Wuster Christopher R. Bauer Teague Sterling Wyatt T. Clark Yuanbin Ru Marena Trinidad Hong Phuc Nguyen Amanda R. Luu Daniel J. Wendt Gouri Yogalingam Guoying Karen Yu Jonathan H. LeBowitz Lon R. Cardon
author_facet	Karol Estrada Steven Froelich Arthur Wuster Christopher R. Bauer Teague Sterling Wyatt T. Clark Yuanbin Ru Marena Trinidad Hong Phuc Nguyen Amanda R. Luu Daniel J. Wendt Gouri Yogalingam Guoying Karen Yu Jonathan H. LeBowitz Lon R. Cardon
author_sort	Karol Estrada
title	Identifying therapeutic drug targets using bidirectional effect genes
title_short	Identifying therapeutic drug targets using bidirectional effect genes
title_full	Identifying therapeutic drug targets using bidirectional effect genes
title_fullStr	Identifying therapeutic drug targets using bidirectional effect genes
title_full_unstemmed	Identifying therapeutic drug targets using bidirectional effect genes
title_sort	identifying therapeutic drug targets using bidirectional effect genes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc9abc10fee1429d8bd83e6241883e5f
work_keys_str_mv	AT karolestrada identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT stevenfroelich identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT arthurwuster identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT christopherrbauer identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT teaguesterling identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT wyatttclark identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT yuanbinru identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT marenatrinidad identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT hongphucnguyen identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT amandarluu identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT danieljwendt identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT gouriyogalingam identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT guoyingkarenyu identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT jonathanhlebowitz identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes AT lonrcardon identifyingtherapeuticdrugtargetsusingbidirectionaleffectgenes
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Identifying therapeutic drug targets using bidirectional effect genes

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