Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases

Abstract Envenoming by viperid snakes results in a complex pattern of tissue damage, including hemorrhage, which in severe cases may lead to permanent sequelae. Snake venom metalloproteinases (SVMPs) are main players in this pathogenesis, acting synergistically upon different mammalian proteomes. He...

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Autores principales: Amanda F. Asega, Milene C. Menezes, Dilza Trevisan-Silva, Daniela Cajado-Carvalho, Luciana Bertholim, Ana K. Oliveira, André Zelanis, Solange M. T. Serrano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bc9c2fbbe69d4ad8ab8d829248f79dbe
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