Dosimetry, control and irradiation of rat cervical spinal cord

Background and Objective: In radiobiology, the most important physical radiation quantity to predict the effect of irradiation of a biological specimen is the absorbed dose to the tissue of interest. In this project an irradiation set up was designed and verification of set up and dosimetry procedur...

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Autores principales:	SR Mahdavi, M Zabih Zadeh, AR Shirazi, H Gharaati
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2005
Materias:	x-ray dosimetry radiobiology rat cervical spinal cord irradiation rat phantom jig Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bc9cfb368ce64c24b6f5d702877b7e10
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spelling	oai:doaj.org-article:bc9cfb368ce64c24b6f5d702877b7e102021-11-10T09:14:32ZDosimetry, control and irradiation of rat cervical spinal cord1561-41072251-7170https://doaj.org/article/bc9cfb368ce64c24b6f5d702877b7e102005-04-01T00:00:00Zhttp://jbums.org/article-1-2630-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: In radiobiology, the most important physical radiation quantity to predict the effect of irradiation of a biological specimen is the absorbed dose to the tissue of interest. In this project an irradiation set up was designed and verification of set up and dosimetry procedure was performed to deliver a precise X-ray dose to the small field of rat cervical spinal cord. Methods: AAPM-TG61 (American association and physician in medicine radiation therapy committee task group 61) protocol was used for dose measurement and we tailored a rat like phantom from polyethylene for dosimetry verification. The ionization chamber in this study was a farmer type and the X-ray generator was an orthovoltage Siemens machine working at 200 KVp potential. Dosimetry was done in air and phantom. An special jig was also built to fix the animals during irradiation which could help the treatments to be reproducible. Simulation and portal films were obtained to verify the irradiation field. Findings: The average value of dose rate in specified geometries by measurement was 146.54 cGy/min (SD=0.109). While the dose determined by calculation was 95.145 cGy/min (SD=0.105), the comparison between these 2 methods shown a small discrepancy of 0.50% (P<0.001), which lies within the error limit of ±5.3% as mentioned by ICRU. Conclusion: Using protocol of AAPM TG-61 can provide an accurate dosimetry with minimum ambiguity. Application of appropriate correction factors and protocols can increase the accuracy and decrease the irradiation errors in radiobiological studies.SR MahdaviM Zabih ZadehAR ShiraziH GharaatiBabol University of Medical Sciencesarticlex-ray dosimetryradiobiologyrat cervical spinal cord irradiationrat phantomjigMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 7, Iss 2, Pp 7-13 (2005)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	x-ray dosimetry radiobiology rat cervical spinal cord irradiation rat phantom jig Medicine R Medicine (General) R5-920
spellingShingle	x-ray dosimetry radiobiology rat cervical spinal cord irradiation rat phantom jig Medicine R Medicine (General) R5-920 SR Mahdavi M Zabih Zadeh AR Shirazi H Gharaati Dosimetry, control and irradiation of rat cervical spinal cord
description	Background and Objective: In radiobiology, the most important physical radiation quantity to predict the effect of irradiation of a biological specimen is the absorbed dose to the tissue of interest. In this project an irradiation set up was designed and verification of set up and dosimetry procedure was performed to deliver a precise X-ray dose to the small field of rat cervical spinal cord. Methods: AAPM-TG61 (American association and physician in medicine radiation therapy committee task group 61) protocol was used for dose measurement and we tailored a rat like phantom from polyethylene for dosimetry verification. The ionization chamber in this study was a farmer type and the X-ray generator was an orthovoltage Siemens machine working at 200 KVp potential. Dosimetry was done in air and phantom. An special jig was also built to fix the animals during irradiation which could help the treatments to be reproducible. Simulation and portal films were obtained to verify the irradiation field. Findings: The average value of dose rate in specified geometries by measurement was 146.54 cGy/min (SD=0.109). While the dose determined by calculation was 95.145 cGy/min (SD=0.105), the comparison between these 2 methods shown a small discrepancy of 0.50% (P<0.001), which lies within the error limit of ±5.3% as mentioned by ICRU. Conclusion: Using protocol of AAPM TG-61 can provide an accurate dosimetry with minimum ambiguity. Application of appropriate correction factors and protocols can increase the accuracy and decrease the irradiation errors in radiobiological studies.
format	article
author	SR Mahdavi M Zabih Zadeh AR Shirazi H Gharaati
author_facet	SR Mahdavi M Zabih Zadeh AR Shirazi H Gharaati
author_sort	SR Mahdavi
title	Dosimetry, control and irradiation of rat cervical spinal cord
title_short	Dosimetry, control and irradiation of rat cervical spinal cord
title_full	Dosimetry, control and irradiation of rat cervical spinal cord
title_fullStr	Dosimetry, control and irradiation of rat cervical spinal cord
title_full_unstemmed	Dosimetry, control and irradiation of rat cervical spinal cord
title_sort	dosimetry, control and irradiation of rat cervical spinal cord
publisher	Babol University of Medical Sciences
publishDate	2005
url	https://doaj.org/article/bc9cfb368ce64c24b6f5d702877b7e10
work_keys_str_mv	AT srmahdavi dosimetrycontrolandirradiationofratcervicalspinalcord AT mzabihzadeh dosimetrycontrolandirradiationofratcervicalspinalcord AT arshirazi dosimetrycontrolandirradiationofratcervicalspinalcord AT hgharaati dosimetrycontrolandirradiationofratcervicalspinalcord
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Dosimetry, control and irradiation of rat cervical spinal cord

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