Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer

The role of non-coding somatic mutations in ovarian cancer is unclear. Here, the authors integrate genomic and epigenomic data from patient samples to show that these mutations frequently converge on the PAX8 transcriptional network.

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Autores principales:	Rosario I. Corona, Ji-Heui Seo, Xianzhi Lin, Dennis J. Hazelett, Jessica Reddy, Marcos A. S. Fonseca, Forough Abassi, Yvonne G. Lin, Paulette Y. Mhawech-Fauceglia, Sohrab P. Shah, David G. Huntsman, Alexander Gusev, Beth Y. Karlan, Benjamin P. Berman, Matthew L. Freedman, Simon A. Gayther, Kate Lawrenson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc9e7a80c70046b095dabebbee18db77
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spelling	oai:doaj.org-article:bc9e7a80c70046b095dabebbee18db772021-12-02T17:31:25ZNon-coding somatic mutations converge on the PAX8 pathway in ovarian cancer10.1038/s41467-020-15951-02041-1723https://doaj.org/article/bc9e7a80c70046b095dabebbee18db772020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15951-0https://doaj.org/toc/2041-1723The role of non-coding somatic mutations in ovarian cancer is unclear. Here, the authors integrate genomic and epigenomic data from patient samples to show that these mutations frequently converge on the PAX8 transcriptional network.Rosario I. CoronaJi-Heui SeoXianzhi LinDennis J. HazelettJessica ReddyMarcos A. S. FonsecaForough AbassiYvonne G. LinPaulette Y. Mhawech-FaucegliaSohrab P. ShahDavid G. HuntsmanAlexander GusevBeth Y. KarlanBenjamin P. BermanMatthew L. FreedmanSimon A. GaytherKate LawrensonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rosario I. Corona Ji-Heui Seo Xianzhi Lin Dennis J. Hazelett Jessica Reddy Marcos A. S. Fonseca Forough Abassi Yvonne G. Lin Paulette Y. Mhawech-Fauceglia Sohrab P. Shah David G. Huntsman Alexander Gusev Beth Y. Karlan Benjamin P. Berman Matthew L. Freedman Simon A. Gayther Kate Lawrenson Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
description	The role of non-coding somatic mutations in ovarian cancer is unclear. Here, the authors integrate genomic and epigenomic data from patient samples to show that these mutations frequently converge on the PAX8 transcriptional network.
format	article
author	Rosario I. Corona Ji-Heui Seo Xianzhi Lin Dennis J. Hazelett Jessica Reddy Marcos A. S. Fonseca Forough Abassi Yvonne G. Lin Paulette Y. Mhawech-Fauceglia Sohrab P. Shah David G. Huntsman Alexander Gusev Beth Y. Karlan Benjamin P. Berman Matthew L. Freedman Simon A. Gayther Kate Lawrenson
author_facet	Rosario I. Corona Ji-Heui Seo Xianzhi Lin Dennis J. Hazelett Jessica Reddy Marcos A. S. Fonseca Forough Abassi Yvonne G. Lin Paulette Y. Mhawech-Fauceglia Sohrab P. Shah David G. Huntsman Alexander Gusev Beth Y. Karlan Benjamin P. Berman Matthew L. Freedman Simon A. Gayther Kate Lawrenson
author_sort	Rosario I. Corona
title	Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
title_short	Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
title_full	Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
title_fullStr	Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
title_full_unstemmed	Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
title_sort	non-coding somatic mutations converge on the pax8 pathway in ovarian cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bc9e7a80c70046b095dabebbee18db77
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Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer

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