miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis

Abstract Human papilloma virus (HPV) vaccine is currently the most effective prophylaxis to prevent cervical cancer. However, concerns regarding its potential severe adverse reactions have limited the vaccination rate. HPV vaccines have been determined to contain adjuvants which induce inflammation...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Momoka Nakashima, Kana Ishikawa, Aika Fugiwara, Kaiin Shu, Yoshimi Fukushima, Masaaki Okamoto, Hirotake Tsukamoto, Takahisa Kouwaki, Hiroyuki Oshiumi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bca120a95fc14916a0fbc270900c67e0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bca120a95fc14916a0fbc270900c67e0
record_format	dspace
spelling	oai:doaj.org-article:bca120a95fc14916a0fbc270900c67e02021-12-02T17:39:19ZmiR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis10.1038/s41598-021-88842-z2045-2322https://doaj.org/article/bca120a95fc14916a0fbc270900c67e02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88842-zhttps://doaj.org/toc/2045-2322Abstract Human papilloma virus (HPV) vaccine is currently the most effective prophylaxis to prevent cervical cancer. However, concerns regarding its potential severe adverse reactions have limited the vaccination rate. HPV vaccines have been determined to contain adjuvants which induce inflammation by the innate immune system and are crucial for triggering adaptive immunity. MicroRNA-451a (miR-451a) is located within circulating extracellular vesicles (EVs) and regulates the innate immune response. In this study, we examined the effect of HPV vaccines and EV miR-451a on murine experimental autoimmune encephalomyelitis (EAE), which is an autoimmune disorder that affects the central nervous system. Although HPV vaccine induced pro-inflammatory cytokine expression and macrophage cell death, it failed to exacerbate mouse EAE, whereas circulating EV miR-451a levels were associated with the severity of EAE. Since miR-451a knockout exhibited only marginal effect on the murine EAE clinical score, our data suggest that miR-451a levels reflect an unknown condition associated with EAE severity. Interestingly, excessive uptake of glucose increased EV miR-451a levels both in vitro and in vivo and also exacerbated mouse EAE. Therefore, environmental factors that increase EV miR-451a levels exacerbate the autoimmune disorder more than the HPV vaccine. These observations provide evidence for the safety of HPV vaccines.Momoka NakashimaKana IshikawaAika FugiwaraKaiin ShuYoshimi FukushimaMasaaki OkamotoHirotake TsukamotoTakahisa KouwakiHiroyuki OshiumiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Momoka Nakashima Kana Ishikawa Aika Fugiwara Kaiin Shu Yoshimi Fukushima Masaaki Okamoto Hirotake Tsukamoto Takahisa Kouwaki Hiroyuki Oshiumi miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
description	Abstract Human papilloma virus (HPV) vaccine is currently the most effective prophylaxis to prevent cervical cancer. However, concerns regarding its potential severe adverse reactions have limited the vaccination rate. HPV vaccines have been determined to contain adjuvants which induce inflammation by the innate immune system and are crucial for triggering adaptive immunity. MicroRNA-451a (miR-451a) is located within circulating extracellular vesicles (EVs) and regulates the innate immune response. In this study, we examined the effect of HPV vaccines and EV miR-451a on murine experimental autoimmune encephalomyelitis (EAE), which is an autoimmune disorder that affects the central nervous system. Although HPV vaccine induced pro-inflammatory cytokine expression and macrophage cell death, it failed to exacerbate mouse EAE, whereas circulating EV miR-451a levels were associated with the severity of EAE. Since miR-451a knockout exhibited only marginal effect on the murine EAE clinical score, our data suggest that miR-451a levels reflect an unknown condition associated with EAE severity. Interestingly, excessive uptake of glucose increased EV miR-451a levels both in vitro and in vivo and also exacerbated mouse EAE. Therefore, environmental factors that increase EV miR-451a levels exacerbate the autoimmune disorder more than the HPV vaccine. These observations provide evidence for the safety of HPV vaccines.
format	article
author	Momoka Nakashima Kana Ishikawa Aika Fugiwara Kaiin Shu Yoshimi Fukushima Masaaki Okamoto Hirotake Tsukamoto Takahisa Kouwaki Hiroyuki Oshiumi
author_facet	Momoka Nakashima Kana Ishikawa Aika Fugiwara Kaiin Shu Yoshimi Fukushima Masaaki Okamoto Hirotake Tsukamoto Takahisa Kouwaki Hiroyuki Oshiumi
author_sort	Momoka Nakashima
title	miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
title_short	miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
title_full	miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
title_fullStr	miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
title_full_unstemmed	miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
title_sort	mir-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bca120a95fc14916a0fbc270900c67e0
work_keys_str_mv	AT momokanakashima mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis AT kanaishikawa mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis AT aikafugiwara mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis AT kaiinshu mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis AT yoshimifukushima mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis AT masaakiokamoto mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis AT hirotaketsukamoto mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis AT takahisakouwaki mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis AT hiroyukioshiumi mir451alevelsratherthanhumanpapillomavirusvaccineadministrationisassociatedwiththeseverityofmurineexperimentalautoimmuneencephalomyelitis
_version_	1718379845141921792

miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis

Ejemplares similares