Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea

Abstract Background There have been reports on regional variation in prevalence of hepatitis B and C, and Clonorchis sinensis (C. sinensis) infection, which indicates potential of spatial variation in liver cancer and gallbladder cancer incidence in Korea. Therefore, we aimed to assess the regional...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Spatial analysis Disease hotspot Liver neoplasms Gallbladder neoplasms Incidence Korea Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/bca7023b6d344dfe8c4031472ea79760
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bca7023b6d344dfe8c4031472ea79760
record_format	dspace
spelling	oai:doaj.org-article:bca7023b6d344dfe8c4031472ea797602021-11-14T12:14:52ZSpatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea10.1186/s12889-021-12184-81471-2458https://doaj.org/article/bca7023b6d344dfe8c4031472ea797602021-11-01T00:00:00Zhttps://doi.org/10.1186/s12889-021-12184-8https://doaj.org/toc/1471-2458Abstract Background There have been reports on regional variation in prevalence of hepatitis B and C, and Clonorchis sinensis (C. sinensis) infection, which indicates potential of spatial variation in liver cancer and gallbladder cancer incidence in Korea. Therefore, we aimed to assess the regional variation of liver and gallbladder cancer incidence and its determinants based on the regional distribution of risk factors, including hepatitis B infection in Korea. Methods This study used an ecological study design and district-level cancer incidence statistics generated by the National Cancer Center. Spatial clusters of liver and gallbladder cancer incidence were detected based on spatial scan statistics using SaTScan™ software. We set the size of maximum spatial scanning window of 25 and 35% of the population at risk for analyses of liver and gallbladder cancer, respectively. Significance level of 0.05 was used to reject the null hypothesis of no cluster. We fitted the Besag-York-Mollie model using integrated nested Laplace approximations to assess factors that influence the regional variation in cancer incidence. Results Spatial clusters with high liver cancer incidence rates were detected in the southwestern and southeastern regions of Korea. High gallbladder cancer incidence rates are clustered in the southeastern region. Regional liver cancer incidence can be accounted for the prevalence of high household income (coefficient, − 0.10; 95% credible interval [CI], − 0.18 to − 0.02), marital status (coefficient, − 0.14; 95% CI, − 0.25 to − 0.03), the incidence of hepatitis B (coefficient, 0.87; 95% CI, 0.29 to 1.44), and liver cancer screening (coefficient, 0.06; 95% CI, 0.00 to 0.12), while gallbladder cancer incidence was related to the prevalence of high household income (coefficient, − 0.03; 95% CI, − 0.05 to 0.00) and living close to a river with a high prevalence of liver fluke infection (coefficient, 0.55; 95% CI, 0.14 to 0.96). Conclusions This study demonstrated geographic variation in liver and gallbladder cancer incidence, which can be explained by determinants such as hepatitis B, income, marital status, and living near a river.Jieun JangDae-Sung YooByung Chul ChunBMCarticleSpatial analysisDisease hotspotLiver neoplasmsGallbladder neoplasmsIncidenceKoreaPublic aspects of medicineRA1-1270ENBMC Public Health, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spatial analysis Disease hotspot Liver neoplasms Gallbladder neoplasms Incidence Korea Public aspects of medicine RA1-1270
spellingShingle	Spatial analysis Disease hotspot Liver neoplasms Gallbladder neoplasms Incidence Korea Public aspects of medicine RA1-1270 Jieun Jang Dae-Sung Yoo Byung Chul Chun Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
description	Abstract Background There have been reports on regional variation in prevalence of hepatitis B and C, and Clonorchis sinensis (C. sinensis) infection, which indicates potential of spatial variation in liver cancer and gallbladder cancer incidence in Korea. Therefore, we aimed to assess the regional variation of liver and gallbladder cancer incidence and its determinants based on the regional distribution of risk factors, including hepatitis B infection in Korea. Methods This study used an ecological study design and district-level cancer incidence statistics generated by the National Cancer Center. Spatial clusters of liver and gallbladder cancer incidence were detected based on spatial scan statistics using SaTScan™ software. We set the size of maximum spatial scanning window of 25 and 35% of the population at risk for analyses of liver and gallbladder cancer, respectively. Significance level of 0.05 was used to reject the null hypothesis of no cluster. We fitted the Besag-York-Mollie model using integrated nested Laplace approximations to assess factors that influence the regional variation in cancer incidence. Results Spatial clusters with high liver cancer incidence rates were detected in the southwestern and southeastern regions of Korea. High gallbladder cancer incidence rates are clustered in the southeastern region. Regional liver cancer incidence can be accounted for the prevalence of high household income (coefficient, − 0.10; 95% credible interval [CI], − 0.18 to − 0.02), marital status (coefficient, − 0.14; 95% CI, − 0.25 to − 0.03), the incidence of hepatitis B (coefficient, 0.87; 95% CI, 0.29 to 1.44), and liver cancer screening (coefficient, 0.06; 95% CI, 0.00 to 0.12), while gallbladder cancer incidence was related to the prevalence of high household income (coefficient, − 0.03; 95% CI, − 0.05 to 0.00) and living close to a river with a high prevalence of liver fluke infection (coefficient, 0.55; 95% CI, 0.14 to 0.96). Conclusions This study demonstrated geographic variation in liver and gallbladder cancer incidence, which can be explained by determinants such as hepatitis B, income, marital status, and living near a river.
format	article
author	Jieun Jang Dae-Sung Yoo Byung Chul Chun
author_facet	Jieun Jang Dae-Sung Yoo Byung Chul Chun
author_sort	Jieun Jang
title	Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
title_short	Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
title_full	Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
title_fullStr	Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
title_full_unstemmed	Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
title_sort	spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in south korea
publisher	BMC
publishDate	2021
url	https://doaj.org/article/bca7023b6d344dfe8c4031472ea79760
work_keys_str_mv	AT jieunjang spatialepidemiologicanalysisofthelivercancerandgallbladdercancerincidenceanditsdeterminantsinsouthkorea AT daesungyoo spatialepidemiologicanalysisofthelivercancerandgallbladdercancerincidenceanditsdeterminantsinsouthkorea AT byungchulchun spatialepidemiologicanalysisofthelivercancerandgallbladdercancerincidenceanditsdeterminantsinsouthkorea
_version_	1718429370115162112

Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea

Ejemplares similares