Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock

Abstract The heat shock response is characterized by the transcriptional activation of both hsp genes and noncoding and repeated satellite III DNA sequences located at pericentric heterochromatin. Both events are under the control of Heat Shock Factor I (HSF1). Here we show that under heat shock, HS...

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Autores principales:	Edwige Col, Neda Hoghoughi, Solenne Dufour, Jessica Penin, Sivan Koskas, Virginie Faure, Maria Ouzounova, Hector Hernandez-Vargash, Nicolas Reynoird, Sylvain Daujat, Eric Folco, Marc Vigneron, Robert Schneider, André Verdel, Saadi Khochbin, Zdenko Herceg, Cécile Caron, Claire Vourc’h
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bca9308205324eb9836b10ca9adb63ee
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spelling	oai:doaj.org-article:bca9308205324eb9836b10ca9adb63ee2021-12-02T11:52:18ZBromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock10.1038/s41598-017-05343-82045-2322https://doaj.org/article/bca9308205324eb9836b10ca9adb63ee2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05343-8https://doaj.org/toc/2045-2322Abstract The heat shock response is characterized by the transcriptional activation of both hsp genes and noncoding and repeated satellite III DNA sequences located at pericentric heterochromatin. Both events are under the control of Heat Shock Factor I (HSF1). Here we show that under heat shock, HSF1 recruits major cellular acetyltransferases, GCN5, TIP60 and p300 to pericentric heterochromatin leading to a targeted hyperacetylation of pericentric chromatin. Redistribution of histone acetylation toward pericentric region in turn directs the recruitment of Bromodomain and Extra-Terminal (BET) proteins BRD2, BRD3, BRD4, which are required for satellite III transcription by RNAP II. Altogether we uncover here a critical role for HSF1 in stressed cells relying on the restricted use of histone acetylation signaling over pericentric heterochromatin (HC).Edwige ColNeda HoghoughiSolenne DufourJessica PeninSivan KoskasVirginie FaureMaria OuzounovaHector Hernandez-VargashNicolas ReynoirdSylvain DaujatEric FolcoMarc VigneronRobert SchneiderAndré VerdelSaadi KhochbinZdenko HercegCécile CaronClaire Vourc’hNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Edwige Col Neda Hoghoughi Solenne Dufour Jessica Penin Sivan Koskas Virginie Faure Maria Ouzounova Hector Hernandez-Vargash Nicolas Reynoird Sylvain Daujat Eric Folco Marc Vigneron Robert Schneider André Verdel Saadi Khochbin Zdenko Herceg Cécile Caron Claire Vourc’h Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock
description	Abstract The heat shock response is characterized by the transcriptional activation of both hsp genes and noncoding and repeated satellite III DNA sequences located at pericentric heterochromatin. Both events are under the control of Heat Shock Factor I (HSF1). Here we show that under heat shock, HSF1 recruits major cellular acetyltransferases, GCN5, TIP60 and p300 to pericentric heterochromatin leading to a targeted hyperacetylation of pericentric chromatin. Redistribution of histone acetylation toward pericentric region in turn directs the recruitment of Bromodomain and Extra-Terminal (BET) proteins BRD2, BRD3, BRD4, which are required for satellite III transcription by RNAP II. Altogether we uncover here a critical role for HSF1 in stressed cells relying on the restricted use of histone acetylation signaling over pericentric heterochromatin (HC).
format	article
author	Edwige Col Neda Hoghoughi Solenne Dufour Jessica Penin Sivan Koskas Virginie Faure Maria Ouzounova Hector Hernandez-Vargash Nicolas Reynoird Sylvain Daujat Eric Folco Marc Vigneron Robert Schneider André Verdel Saadi Khochbin Zdenko Herceg Cécile Caron Claire Vourc’h
author_facet	Edwige Col Neda Hoghoughi Solenne Dufour Jessica Penin Sivan Koskas Virginie Faure Maria Ouzounova Hector Hernandez-Vargash Nicolas Reynoird Sylvain Daujat Eric Folco Marc Vigneron Robert Schneider André Verdel Saadi Khochbin Zdenko Herceg Cécile Caron Claire Vourc’h
author_sort	Edwige Col
title	Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock
title_short	Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock
title_full	Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock
title_fullStr	Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock
title_full_unstemmed	Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock
title_sort	bromodomain factors of bet family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bca9308205324eb9836b10ca9adb63ee
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Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock

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