Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder

Takeshi Inoue,1 Toshifumi Kimura,2 Yoshifumi Inagaki,2 Osamu Shirakawa3 1Department of Psychiatry, Tokyo Medical University, Tokyo, Japan; 2Medical Affairs Department, Medical Division, GlaxoSmithKline K.K., Tokyo, Japan; 3Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka,...

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Autores principales:	Inoue T, Kimura T, Inagaki Y, Shirakawa O
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	anxiety disorders bipolar disorder comorbidity major depressive disorder prevalence Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bca9a32156b24bf694d8196d6c706773
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spelling	oai:doaj.org-article:bca9a32156b24bf694d8196d6c7067732021-12-02T10:33:52ZPrevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder1178-2021https://doaj.org/article/bca9a32156b24bf694d8196d6c7067732020-07-01T00:00:00Zhttps://www.dovepress.com/prevalence-of-comorbid-anxiety-disorders-and-their-associated-factors--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Takeshi Inoue,1 Toshifumi Kimura,2 Yoshifumi Inagaki,2 Osamu Shirakawa3 1Department of Psychiatry, Tokyo Medical University, Tokyo, Japan; 2Medical Affairs Department, Medical Division, GlaxoSmithKline K.K., Tokyo, Japan; 3Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka, JapanCorrespondence: Takeshi InoueDepartment of Psychiatry, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-Ku, Tokyo 160-0023, JapanTel +81 3 3342 6111Fax +81 3 3345 1437Email tinoue@tokyo-med.ac.jpObjective: Comorbid anxiety disorders in patients with mood disorders have a negative impact on outcomes, such as persistence of depressive symptoms, deterioration of quality of life (QoL), increased suicide risk, mood instability with antidepressant treatment, but often go underrecognized in clinical practice. To identify features useful for supporting the confirmation of comorbid anxiety disorders, we investigated the prevalence of comorbid anxiety disorders and their associated factors in Japanese patients with mood disorders using data from our previously reported JET-LMBP study.Patients and Methods: Patients with bipolar disorder (BD; n=114) and patients with major depressive disorder (MDD; n=334), all with major depressive episodes (DSM-IV-TR) were analyzed. Comorbid anxiety disorders were confirmed using the Mini-International Neuropsychiatric Interview. Demographic and clinical features were assessed using patient background forms, including the Quick Inventory of Depressive Symptomatology–Self Report Japanese version, 36-Item Short-Form Health Survey (SF-36), and Child Abuse and Trauma Scale (CATS). Multivariate logistic regression analysis adjusted for age, sex, and severity of depressive symptoms was used to identify factors associated with comorbid anxiety disorders (post hoc analysis).Results: The prevalence of comorbid anxiety disorders was significantly higher in patients with BD (53.2%) than in patients with MDD (37.2%). Factors associated with comorbid anxiety disorders in BD included no spouse, interpersonal rejection sensitivity, higher CATS sexual abuse scores, and lower SF-36 mental component summary scores. In MDD, factors included hypersomnia, pathological guilt feelings, higher CATS neglect scores, and lower SF-36 physical component summary scores.Conclusion: Comorbid anxiety disorders were commonly seen in Japanese patients with mood disorders. Childhood abuse, atypical depression symptoms, and deterioration of health-related QoL were commonly associated with comorbid anxiety disorders in BD and MDD, suggesting that the presence of these features may be useful to support the confirmation of comorbid anxiety disorders in these patients.Keywords: anxiety disorders, bipolar disorder, comorbidity, major depressive disorder, prevalenceInoue TKimura TInagaki YShirakawa ODove Medical Pressarticleanxiety disordersbipolar disordercomorbiditymajor depressive disorderprevalenceNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1695-1704 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxiety disorders bipolar disorder comorbidity major depressive disorder prevalence Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	anxiety disorders bipolar disorder comorbidity major depressive disorder prevalence Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Inoue T Kimura T Inagaki Y Shirakawa O Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder
description	Takeshi Inoue,1 Toshifumi Kimura,2 Yoshifumi Inagaki,2 Osamu Shirakawa3 1Department of Psychiatry, Tokyo Medical University, Tokyo, Japan; 2Medical Affairs Department, Medical Division, GlaxoSmithKline K.K., Tokyo, Japan; 3Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka, JapanCorrespondence: Takeshi InoueDepartment of Psychiatry, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-Ku, Tokyo 160-0023, JapanTel +81 3 3342 6111Fax +81 3 3345 1437Email tinoue@tokyo-med.ac.jpObjective: Comorbid anxiety disorders in patients with mood disorders have a negative impact on outcomes, such as persistence of depressive symptoms, deterioration of quality of life (QoL), increased suicide risk, mood instability with antidepressant treatment, but often go underrecognized in clinical practice. To identify features useful for supporting the confirmation of comorbid anxiety disorders, we investigated the prevalence of comorbid anxiety disorders and their associated factors in Japanese patients with mood disorders using data from our previously reported JET-LMBP study.Patients and Methods: Patients with bipolar disorder (BD; n=114) and patients with major depressive disorder (MDD; n=334), all with major depressive episodes (DSM-IV-TR) were analyzed. Comorbid anxiety disorders were confirmed using the Mini-International Neuropsychiatric Interview. Demographic and clinical features were assessed using patient background forms, including the Quick Inventory of Depressive Symptomatology–Self Report Japanese version, 36-Item Short-Form Health Survey (SF-36), and Child Abuse and Trauma Scale (CATS). Multivariate logistic regression analysis adjusted for age, sex, and severity of depressive symptoms was used to identify factors associated with comorbid anxiety disorders (post hoc analysis).Results: The prevalence of comorbid anxiety disorders was significantly higher in patients with BD (53.2%) than in patients with MDD (37.2%). Factors associated with comorbid anxiety disorders in BD included no spouse, interpersonal rejection sensitivity, higher CATS sexual abuse scores, and lower SF-36 mental component summary scores. In MDD, factors included hypersomnia, pathological guilt feelings, higher CATS neglect scores, and lower SF-36 physical component summary scores.Conclusion: Comorbid anxiety disorders were commonly seen in Japanese patients with mood disorders. Childhood abuse, atypical depression symptoms, and deterioration of health-related QoL were commonly associated with comorbid anxiety disorders in BD and MDD, suggesting that the presence of these features may be useful to support the confirmation of comorbid anxiety disorders in these patients.Keywords: anxiety disorders, bipolar disorder, comorbidity, major depressive disorder, prevalence
format	article
author	Inoue T Kimura T Inagaki Y Shirakawa O
author_facet	Inoue T Kimura T Inagaki Y Shirakawa O
author_sort	Inoue T
title	Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder
title_short	Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder
title_full	Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder
title_fullStr	Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder
title_full_unstemmed	Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder
title_sort	prevalence of comorbid anxiety disorders and their associated factors in patients with bipolar disorder or major depressive disorder
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bca9a32156b24bf694d8196d6c706773
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Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder

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