CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients

You-ting Lin,1 Xue Yang,2 Jing-wei Lv,2 Xue-wu Liu,2,* Sheng-jun Wang2,* 1Department of Neurology, Shandong Provincial Hospital, Shandong University, Ji’nan, People’s Republic of China; 2Department of Neurology, Qilu Hospital, Shandong University, Ji’nan, People&rsq...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lin Y, Yang X, Lv J, Liu X, Wang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	leucine-rich glioma-inactivated protein 1 CXCL13 cytokine encephalitis biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bcad2b20d19e46ea957cd8118e8661f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bcad2b20d19e46ea957cd8118e8661f9
record_format	dspace
spelling	oai:doaj.org-article:bcad2b20d19e46ea957cd8118e8661f92021-12-02T10:40:52ZCXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients1178-2021https://doaj.org/article/bcad2b20d19e46ea957cd8118e8661f92019-10-01T00:00:00Zhttps://www.dovepress.com/cxcl13-is-a-biomarker-of-anti-leucine-rich-glioma-inactivated-protein--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021You-ting Lin,1 Xue Yang,2 Jing-wei Lv,2 Xue-wu Liu,2,* Sheng-jun Wang2,* 1Department of Neurology, Shandong Provincial Hospital, Shandong University, Ji’nan, People’s Republic of China; 2Department of Neurology, Qilu Hospital, Shandong University, Ji’nan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheng-jun Wang;Xue-wu LiuDepartment of Neurology, Qilu Hospital, Shandong University, 107# Wen Hua Xi Road, Ji’nan 250012, Peoples Republic of ChinaEmail junwang9999@sina.com; qiluliuym66@163.comBackground: Although antibody-mediated immune responses are considered pathogenic and responsible for neural injury in anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis, previous studies have indicated that cytokines and chemokines might play roles in the pathogenic process by serving as B cell enhancers. In this study, we detected the profiles of cytokines and chemokines in the cerebral fluid (CSF) and serum of patients with anti-LGI1 encephalitis to identify potential biomarkers.Methods: Sixteen patients diagnosed with anti-LGI1 encephalitis and nine patients diagnosed with noninflammatory neurologic disorders were included in the study. Cytokines and chemokines including IL-6, IL-10, IL-17, CXCL12, CXCL13, BAFF and HMGB1 in serum and CSF were measured.Results: The serum and CSF levels of CXCL13 were significantly higher in patients with anti-LGI1 encephalitis (36.32±34.71 pg/mL and 2.23±2.41 pg/mL, respectively) than in controls (10.84±5.02 pg/mL and 0.34±0.21 pg/mL, respectively). There was no significant difference in serum or CSF levels of IL-6, IL-10, IL-17, CXCL12, BAFF and HMGB1 between the two groups.Conclusion: CXCL13 is a potential biomarker of active inflammation in anti-LGI1 encephalitis. The distinctive response of cytokines and chemokines might be closely linked to the mechanisms underlying this condition.Keywords: leucine-rich glioma-inactivated protein 1, CXCL13, cytokine, encephalitis, biomarkerLin YYang XLv JLiu XWang SDove Medical Pressarticleleucine-rich glioma-inactivated protein 1CXCL13cytokineencephalitisbiomarkerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2909-2915 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	leucine-rich glioma-inactivated protein 1 CXCL13 cytokine encephalitis biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	leucine-rich glioma-inactivated protein 1 CXCL13 cytokine encephalitis biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lin Y Yang X Lv J Liu X Wang S CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients
description	You-ting Lin,1 Xue Yang,2 Jing-wei Lv,2 Xue-wu Liu,2,* Sheng-jun Wang2,* 1Department of Neurology, Shandong Provincial Hospital, Shandong University, Ji’nan, People’s Republic of China; 2Department of Neurology, Qilu Hospital, Shandong University, Ji’nan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheng-jun Wang;Xue-wu LiuDepartment of Neurology, Qilu Hospital, Shandong University, 107# Wen Hua Xi Road, Ji’nan 250012, Peoples Republic of ChinaEmail junwang9999@sina.com; qiluliuym66@163.comBackground: Although antibody-mediated immune responses are considered pathogenic and responsible for neural injury in anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis, previous studies have indicated that cytokines and chemokines might play roles in the pathogenic process by serving as B cell enhancers. In this study, we detected the profiles of cytokines and chemokines in the cerebral fluid (CSF) and serum of patients with anti-LGI1 encephalitis to identify potential biomarkers.Methods: Sixteen patients diagnosed with anti-LGI1 encephalitis and nine patients diagnosed with noninflammatory neurologic disorders were included in the study. Cytokines and chemokines including IL-6, IL-10, IL-17, CXCL12, CXCL13, BAFF and HMGB1 in serum and CSF were measured.Results: The serum and CSF levels of CXCL13 were significantly higher in patients with anti-LGI1 encephalitis (36.32±34.71 pg/mL and 2.23±2.41 pg/mL, respectively) than in controls (10.84±5.02 pg/mL and 0.34±0.21 pg/mL, respectively). There was no significant difference in serum or CSF levels of IL-6, IL-10, IL-17, CXCL12, BAFF and HMGB1 between the two groups.Conclusion: CXCL13 is a potential biomarker of active inflammation in anti-LGI1 encephalitis. The distinctive response of cytokines and chemokines might be closely linked to the mechanisms underlying this condition.Keywords: leucine-rich glioma-inactivated protein 1, CXCL13, cytokine, encephalitis, biomarker
format	article
author	Lin Y Yang X Lv J Liu X Wang S
author_facet	Lin Y Yang X Lv J Liu X Wang S
author_sort	Lin Y
title	CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients
title_short	CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients
title_full	CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients
title_fullStr	CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients
title_full_unstemmed	CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients
title_sort	cxcl13 is a biomarker of anti-leucine-rich glioma-inactivated protein 1 encephalitis patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/bcad2b20d19e46ea957cd8118e8661f9
work_keys_str_mv	AT liny cxcl13isabiomarkerofantileucinerichgliomainactivatedprotein1encephalitispatients AT yangx cxcl13isabiomarkerofantileucinerichgliomainactivatedprotein1encephalitispatients AT lvj cxcl13isabiomarkerofantileucinerichgliomainactivatedprotein1encephalitispatients AT liux cxcl13isabiomarkerofantileucinerichgliomainactivatedprotein1encephalitispatients AT wangs cxcl13isabiomarkerofantileucinerichgliomainactivatedprotein1encephalitispatients
_version_	1718396852114554880

CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients

Ejemplares similares