Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis
Abstract Electrocautery is a promising treatment option for patients with Hunner type interstitial cystitis (HIC), but frequently requires multiple sessions due to recurrence of the lesions. In the present study, we assessed the relationship between the frequency of electrocautery of Hunner lesions...
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2021
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oai:doaj.org-article:bcadcfc070fc439ca7ffd9c5280dbf062021-12-02T11:46:06ZRelationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis10.1038/s41598-020-80589-32045-2322https://doaj.org/article/bcadcfc070fc439ca7ffd9c5280dbf062021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80589-3https://doaj.org/toc/2045-2322Abstract Electrocautery is a promising treatment option for patients with Hunner type interstitial cystitis (HIC), but frequently requires multiple sessions due to recurrence of the lesions. In the present study, we assessed the relationship between the frequency of electrocautery of Hunner lesions and changes in maximum bladder capacity (MBC) at hydrodistension in a large cohort of 118 HIC patients. Three mixed-effect linear regression analyses were conducted for MBC against (1) the number of sessions; (2) the number of sessions and the time between each session and the first session; and (3) other relevant clinical parameters in addition to the Model (2). The mean number of sessions was 2.8 times. MBC decreased approximately 50 mL for each additional electrocautery session, but this loss was offset by 10 mL for each year the subsequent session was postponed. MBC of < 400 mL at the first session was a significant risk factor for MBC loss with further sessions. No other clinical parameters were associated with MBC over time. This study demonstrates a significant relationship between the frequency of electrocautery of Hunner lesions and MBC changes in HIC patients. Low MBC at the first session is a poor prognostic marker for MBC loss over multiple sessions.Yoshiyuki AkiyamaMasayoshi ZaitsuDaiji WatanabeItsuki YoshimuraAya NiimiAkira NomiyaYuta YamadaYusuke SatoMasaki NakamuraTaketo KawaiDaisuke YamadaMotofumi SuzukiHaruki KumeYukio HommaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Yoshiyuki Akiyama Masayoshi Zaitsu Daiji Watanabe Itsuki Yoshimura Aya Niimi Akira Nomiya Yuta Yamada Yusuke Sato Masaki Nakamura Taketo Kawai Daisuke Yamada Motofumi Suzuki Haruki Kume Yukio Homma Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis |
| description |
Abstract Electrocautery is a promising treatment option for patients with Hunner type interstitial cystitis (HIC), but frequently requires multiple sessions due to recurrence of the lesions. In the present study, we assessed the relationship between the frequency of electrocautery of Hunner lesions and changes in maximum bladder capacity (MBC) at hydrodistension in a large cohort of 118 HIC patients. Three mixed-effect linear regression analyses were conducted for MBC against (1) the number of sessions; (2) the number of sessions and the time between each session and the first session; and (3) other relevant clinical parameters in addition to the Model (2). The mean number of sessions was 2.8 times. MBC decreased approximately 50 mL for each additional electrocautery session, but this loss was offset by 10 mL for each year the subsequent session was postponed. MBC of < 400 mL at the first session was a significant risk factor for MBC loss with further sessions. No other clinical parameters were associated with MBC over time. This study demonstrates a significant relationship between the frequency of electrocautery of Hunner lesions and MBC changes in HIC patients. Low MBC at the first session is a poor prognostic marker for MBC loss over multiple sessions. |
| format |
article |
| author |
Yoshiyuki Akiyama Masayoshi Zaitsu Daiji Watanabe Itsuki Yoshimura Aya Niimi Akira Nomiya Yuta Yamada Yusuke Sato Masaki Nakamura Taketo Kawai Daisuke Yamada Motofumi Suzuki Haruki Kume Yukio Homma |
| author_facet |
Yoshiyuki Akiyama Masayoshi Zaitsu Daiji Watanabe Itsuki Yoshimura Aya Niimi Akira Nomiya Yuta Yamada Yusuke Sato Masaki Nakamura Taketo Kawai Daisuke Yamada Motofumi Suzuki Haruki Kume Yukio Homma |
| author_sort |
Yoshiyuki Akiyama |
| title |
Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis |
| title_short |
Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis |
| title_full |
Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis |
| title_fullStr |
Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis |
| title_full_unstemmed |
Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis |
| title_sort |
relationship between the frequency of electrocautery of hunner lesions and changes in bladder capacity in patients with hunner type interstitial cystitis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/bcadcfc070fc439ca7ffd9c5280dbf06 |
| work_keys_str_mv |
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