Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter

The human serotonin transporter (SERT) mediates the uptake of neurotransmitters to terminate neuronal signalling. Here the authors use single-molecule imaging to get insight into the molecular origin of SERT oligomerization and their pre-set stoichiometry at the plasma membrane.

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Autores principales:	Andreas Anderluh, Tina Hofmaier, Enrico Klotzsch, Oliver Kudlacek, Thomas Stockner, Harald H. Sitte, Gerhard J. Schütz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bcb1096f3d314ab090f13b2d7e457d58
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spelling	oai:doaj.org-article:bcb1096f3d314ab090f13b2d7e457d582021-12-02T14:42:46ZDirect PIP2 binding mediates stable oligomer formation of the serotonin transporter10.1038/ncomms140892041-1723https://doaj.org/article/bcb1096f3d314ab090f13b2d7e457d582017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14089https://doaj.org/toc/2041-1723The human serotonin transporter (SERT) mediates the uptake of neurotransmitters to terminate neuronal signalling. Here the authors use single-molecule imaging to get insight into the molecular origin of SERT oligomerization and their pre-set stoichiometry at the plasma membrane.Andreas AnderluhTina HofmaierEnrico KlotzschOliver KudlacekThomas StocknerHarald H. SitteGerhard J. SchützNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreas Anderluh Tina Hofmaier Enrico Klotzsch Oliver Kudlacek Thomas Stockner Harald H. Sitte Gerhard J. Schütz Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter
description	The human serotonin transporter (SERT) mediates the uptake of neurotransmitters to terminate neuronal signalling. Here the authors use single-molecule imaging to get insight into the molecular origin of SERT oligomerization and their pre-set stoichiometry at the plasma membrane.
format	article
author	Andreas Anderluh Tina Hofmaier Enrico Klotzsch Oliver Kudlacek Thomas Stockner Harald H. Sitte Gerhard J. Schütz
author_facet	Andreas Anderluh Tina Hofmaier Enrico Klotzsch Oliver Kudlacek Thomas Stockner Harald H. Sitte Gerhard J. Schütz
author_sort	Andreas Anderluh
title	Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter
title_short	Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter
title_full	Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter
title_fullStr	Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter
title_full_unstemmed	Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter
title_sort	direct pip2 binding mediates stable oligomer formation of the serotonin transporter
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bcb1096f3d314ab090f13b2d7e457d58
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Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter

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