Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

The present study compares the structure and composition of fascia lata in healthy subjects and in patients with hip osteoarthritis (OA), to evaluate any differences in the amount of Collagen type I, Collagen type III, and Hyaluronan. Fascia lata samples from voluntary healthy subjects and patients...

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Autores principales:	Ilaria Fantoni, Carlo Biz, Chenglei Fan, Carmelo Pirri, Caterina Fede, Lucia Petrelli, Pietro Ruggieri, Raffaele De Caro, Carla Stecco
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fascia hip osteoarthritis hyaluronan collagen stiffness myofascial pain Science Q
Acceso en línea:	https://doaj.org/article/bcb4269e7c11442d864274148d2cfa63
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spelling	oai:doaj.org-article:bcb4269e7c11442d864274148d2cfa632021-11-25T18:10:34ZFascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study10.3390/life111111362075-1729https://doaj.org/article/bcb4269e7c11442d864274148d2cfa632021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1136https://doaj.org/toc/2075-1729The present study compares the structure and composition of fascia lata in healthy subjects and in patients with hip osteoarthritis (OA), to evaluate any differences in the amount of Collagen type I, Collagen type III, and Hyaluronan. Fascia lata samples from voluntary healthy subjects and patients with OA were harvested during surgery. Collagen type I (COL I), III (COL III) antibody, and biotinylated hyaluronan binding protein (HABP) immunohistochemistry stainings were used to evaluate fascial morphology and COL I, COL III, and Hyaluronan (HA) content in both groups. Ten samples from healthy subjects and 11 samples from OA patients were collected. COL I was significantly more abundant in the OA group (<i>p =</i> 0.0015), with a median percentage positivity of 75.2 (IQR 13.11)%, while representing only 67 (IQR: 8.71)% in control cases. COL III, with median values of 9.5 (IQR 3.63)% (OA group) and 17.10 (IQR 11)% (control cases), respectively, showed significant reduction in OA patients (<i>p =</i> 0.002). HA showed a median value of 10.01 (IQR 8.11)% in OA patients, denoting significant decrease (<i>p <</i> 0.0001) with respect to the control group median 39.31 (IQR 5.62)%. The observed differences suggest a relationship between fascial pathology and hip OA. The observed increase in COL I in OA patients, along with the reduction of COL III and HA, could lead to fascial stiffening, which could alter fascial mechanics and be linked to the development and symptoms of OA.Ilaria FantoniCarlo BizChenglei FanCarmelo PirriCaterina FedeLucia PetrelliPietro RuggieriRaffaele De CaroCarla SteccoMDPI AGarticlefasciahip osteoarthritishyaluronancollagenstiffnessmyofascial painScienceQENLife, Vol 11, Iss 1136, p 1136 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fascia hip osteoarthritis hyaluronan collagen stiffness myofascial pain Science Q
spellingShingle	fascia hip osteoarthritis hyaluronan collagen stiffness myofascial pain Science Q Ilaria Fantoni Carlo Biz Chenglei Fan Carmelo Pirri Caterina Fede Lucia Petrelli Pietro Ruggieri Raffaele De Caro Carla Stecco Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study
description	The present study compares the structure and composition of fascia lata in healthy subjects and in patients with hip osteoarthritis (OA), to evaluate any differences in the amount of Collagen type I, Collagen type III, and Hyaluronan. Fascia lata samples from voluntary healthy subjects and patients with OA were harvested during surgery. Collagen type I (COL I), III (COL III) antibody, and biotinylated hyaluronan binding protein (HABP) immunohistochemistry stainings were used to evaluate fascial morphology and COL I, COL III, and Hyaluronan (HA) content in both groups. Ten samples from healthy subjects and 11 samples from OA patients were collected. COL I was significantly more abundant in the OA group (<i>p =</i> 0.0015), with a median percentage positivity of 75.2 (IQR 13.11)%, while representing only 67 (IQR: 8.71)% in control cases. COL III, with median values of 9.5 (IQR 3.63)% (OA group) and 17.10 (IQR 11)% (control cases), respectively, showed significant reduction in OA patients (<i>p =</i> 0.002). HA showed a median value of 10.01 (IQR 8.11)% in OA patients, denoting significant decrease (<i>p <</i> 0.0001) with respect to the control group median 39.31 (IQR 5.62)%. The observed differences suggest a relationship between fascial pathology and hip OA. The observed increase in COL I in OA patients, along with the reduction of COL III and HA, could lead to fascial stiffening, which could alter fascial mechanics and be linked to the development and symptoms of OA.
format	article
author	Ilaria Fantoni Carlo Biz Chenglei Fan Carmelo Pirri Caterina Fede Lucia Petrelli Pietro Ruggieri Raffaele De Caro Carla Stecco
author_facet	Ilaria Fantoni Carlo Biz Chenglei Fan Carmelo Pirri Caterina Fede Lucia Petrelli Pietro Ruggieri Raffaele De Caro Carla Stecco
author_sort	Ilaria Fantoni
title	Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study
title_short	Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study
title_full	Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study
title_fullStr	Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study
title_full_unstemmed	Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study
title_sort	fascia lata alterations in hip osteoarthritis: an observational cross-sectional study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bcb4269e7c11442d864274148d2cfa63
work_keys_str_mv	AT ilariafantoni fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy AT carlobiz fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy AT chengleifan fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy AT carmelopirri fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy AT caterinafede fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy AT luciapetrelli fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy AT pietroruggieri fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy AT raffaeledecaro fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy AT carlastecco fascialataalterationsinhiposteoarthritisanobservationalcrosssectionalstudy
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Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

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