Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.

Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal stri...

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Autores principales:	Christopher J Hyatt, Michal Assaf, Christine E Muska, Rivkah I Rosen, Andre D Thomas, Matthew R Johnson, Jennifer L Hylton, Melissa M Andrews, Brady A Reynolds, John H Krystal, Marc N Potenza, Godfrey D Pearlson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bcb7305d84f84d1885c158ccb3509243
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spelling	oai:doaj.org-article:bcb7305d84f84d1885c158ccb35092432021-11-18T07:18:47ZReward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.1932-620310.1371/journal.pone.0034917https://doaj.org/article/bcb7305d84f84d1885c158ccb35092432012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22606228/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).Christopher J HyattMichal AssafChristine E MuskaRivkah I RosenAndre D ThomasMatthew R JohnsonJennifer L HyltonMelissa M AndrewsBrady A ReynoldsJohn H KrystalMarc N PotenzaGodfrey D PearlsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e34917 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christopher J Hyatt Michal Assaf Christine E Muska Rivkah I Rosen Andre D Thomas Matthew R Johnson Jennifer L Hylton Melissa M Andrews Brady A Reynolds John H Krystal Marc N Potenza Godfrey D Pearlson Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.
description	Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).
format	article
author	Christopher J Hyatt Michal Assaf Christine E Muska Rivkah I Rosen Andre D Thomas Matthew R Johnson Jennifer L Hylton Melissa M Andrews Brady A Reynolds John H Krystal Marc N Potenza Godfrey D Pearlson
author_facet	Christopher J Hyatt Michal Assaf Christine E Muska Rivkah I Rosen Andre D Thomas Matthew R Johnson Jennifer L Hylton Melissa M Andrews Brady A Reynolds John H Krystal Marc N Potenza Godfrey D Pearlson
author_sort	Christopher J Hyatt
title	Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.
title_short	Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.
title_full	Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.
title_fullStr	Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.
title_full_unstemmed	Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.
title_sort	reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/bcb7305d84f84d1885c158ccb3509243
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Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.

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