Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.

Danshensu, a type of dihydroxyphenyl lactic acid, is one of the most abundant active phenolic acids in the dried root of Salvia miltiorrhizae (Lamiaceae)--widely used traditional Chinese medicine. The effects of danshensu on platelet aggregation and thrombus formation in rats were examined using var...

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Autores principales:	Chen Yu, Dong Qi, Wei Lian, Qing-Zhong Li, Hong-Juan Li, Hua-Ying Fan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bcc93bed50c34805b22ed0d30cf181a0
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spelling	oai:doaj.org-article:bcc93bed50c34805b22ed0d30cf181a02021-11-25T05:54:32ZEffects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.1932-620310.1371/journal.pone.0110124https://doaj.org/article/bcc93bed50c34805b22ed0d30cf181a02014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110124https://doaj.org/toc/1932-6203Danshensu, a type of dihydroxyphenyl lactic acid, is one of the most abundant active phenolic acids in the dried root of Salvia miltiorrhizae (Lamiaceae)--widely used traditional Chinese medicine. The effects of danshensu on platelet aggregation and thrombus formation in rats were examined using various methods. It was found that danshensu significantly reduced thrombus weight in 2 experimental thrombosis models; dose-dependent inhibition of adenosine diphosphate (ADP) and arachidonic acid (AA)-induced platelet aggregation occurred in normal and blood stasis-induced rats; Danshensu also significantly mitigated blood viscosity, plasma viscosity and hematocrit levels. Moreover, danshensu significantly inhibited venous thrombosis-induced expression of cyclooxygenases-2 (COX-2) rather than cyclooxygenases-1(COX-1) in the venous walls, down regulated thromboxane B2 (TXB2) and up regulated 6-keto prostaglandin F1α (6-keto-PGF1α), normalizing the TXB2/6-keto-PGF1α ratio. In addition, danshensu did not induce gastric lesions and even had protective effects on aspirin-induced ulcer formation at doses as high as 60 mg/kg. These findings suggest that the antithrombotic and antiplatelet aggregation effects of danshensu are attributed to its highly selective inhibition of COX-2 and ability to normalize the thromboxane A2(TXA2)/prostacyclin(PGI2) balance. These findings suggest that danshensu have great prospects in antithrombotic and antiplatelet therapy.Chen YuDong QiWei LianQing-Zhong LiHong-Juan LiHua-Ying FanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 11, p e110124 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chen Yu Dong Qi Wei Lian Qing-Zhong Li Hong-Juan Li Hua-Ying Fan Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
description	Danshensu, a type of dihydroxyphenyl lactic acid, is one of the most abundant active phenolic acids in the dried root of Salvia miltiorrhizae (Lamiaceae)--widely used traditional Chinese medicine. The effects of danshensu on platelet aggregation and thrombus formation in rats were examined using various methods. It was found that danshensu significantly reduced thrombus weight in 2 experimental thrombosis models; dose-dependent inhibition of adenosine diphosphate (ADP) and arachidonic acid (AA)-induced platelet aggregation occurred in normal and blood stasis-induced rats; Danshensu also significantly mitigated blood viscosity, plasma viscosity and hematocrit levels. Moreover, danshensu significantly inhibited venous thrombosis-induced expression of cyclooxygenases-2 (COX-2) rather than cyclooxygenases-1(COX-1) in the venous walls, down regulated thromboxane B2 (TXB2) and up regulated 6-keto prostaglandin F1α (6-keto-PGF1α), normalizing the TXB2/6-keto-PGF1α ratio. In addition, danshensu did not induce gastric lesions and even had protective effects on aspirin-induced ulcer formation at doses as high as 60 mg/kg. These findings suggest that the antithrombotic and antiplatelet aggregation effects of danshensu are attributed to its highly selective inhibition of COX-2 and ability to normalize the thromboxane A2(TXA2)/prostacyclin(PGI2) balance. These findings suggest that danshensu have great prospects in antithrombotic and antiplatelet therapy.
format	article
author	Chen Yu Dong Qi Wei Lian Qing-Zhong Li Hong-Juan Li Hua-Ying Fan
author_facet	Chen Yu Dong Qi Wei Lian Qing-Zhong Li Hong-Juan Li Hua-Ying Fan
author_sort	Chen Yu
title	Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
title_short	Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
title_full	Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
title_fullStr	Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
title_full_unstemmed	Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
title_sort	effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/bcc93bed50c34805b22ed0d30cf181a0
work_keys_str_mv	AT chenyu effectsofdanshensuonplateletaggregationandthrombosisinvivoarteriovenousshuntandvenousthrombosismodelsinrats AT dongqi effectsofdanshensuonplateletaggregationandthrombosisinvivoarteriovenousshuntandvenousthrombosismodelsinrats AT weilian effectsofdanshensuonplateletaggregationandthrombosisinvivoarteriovenousshuntandvenousthrombosismodelsinrats AT qingzhongli effectsofdanshensuonplateletaggregationandthrombosisinvivoarteriovenousshuntandvenousthrombosismodelsinrats AT hongjuanli effectsofdanshensuonplateletaggregationandthrombosisinvivoarteriovenousshuntandvenousthrombosismodelsinrats AT huayingfan effectsofdanshensuonplateletaggregationandthrombosisinvivoarteriovenousshuntandvenousthrombosismodelsinrats
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Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.

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