An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer

IL-2/anti-IL-2 complexes have been proposed to curtail the severe adverse effects associated with IL-2 immunotherapy. Here, the authors, by integrating unmutated human IL-2 in the antigen binding groove of an anti-IL-2 monoclonal antibody, generate a CD122-biased fusion protein that prevents binding...

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Autores principales: Dilara Sahin, Natalia Arenas-Ramirez, Matthias Rath, Ufuk Karakus, Monika Hümbelin, Merel van Gogh, Lubor Borsig, Onur Boyman
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bccae141645e49d6828a1fe5efe66a25
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spelling oai:doaj.org-article:bccae141645e49d6828a1fe5efe66a252021-12-02T14:16:05ZAn IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer10.1038/s41467-020-20220-12041-1723https://doaj.org/article/bccae141645e49d6828a1fe5efe66a252020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20220-1https://doaj.org/toc/2041-1723IL-2/anti-IL-2 complexes have been proposed to curtail the severe adverse effects associated with IL-2 immunotherapy. Here, the authors, by integrating unmutated human IL-2 in the antigen binding groove of an anti-IL-2 monoclonal antibody, generate a CD122-biased fusion protein that prevents binding of IL-2 to CD25 and promotes anti-tumor immune response in several preclinical metastatic cancer models.Dilara SahinNatalia Arenas-RamirezMatthias RathUfuk KarakusMonika HümbelinMerel van GoghLubor BorsigOnur BoymanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dilara Sahin
Natalia Arenas-Ramirez
Matthias Rath
Ufuk Karakus
Monika Hümbelin
Merel van Gogh
Lubor Borsig
Onur Boyman
An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer
description IL-2/anti-IL-2 complexes have been proposed to curtail the severe adverse effects associated with IL-2 immunotherapy. Here, the authors, by integrating unmutated human IL-2 in the antigen binding groove of an anti-IL-2 monoclonal antibody, generate a CD122-biased fusion protein that prevents binding of IL-2 to CD25 and promotes anti-tumor immune response in several preclinical metastatic cancer models.
format article
author Dilara Sahin
Natalia Arenas-Ramirez
Matthias Rath
Ufuk Karakus
Monika Hümbelin
Merel van Gogh
Lubor Borsig
Onur Boyman
author_facet Dilara Sahin
Natalia Arenas-Ramirez
Matthias Rath
Ufuk Karakus
Monika Hümbelin
Merel van Gogh
Lubor Borsig
Onur Boyman
author_sort Dilara Sahin
title An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer
title_short An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer
title_full An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer
title_fullStr An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer
title_full_unstemmed An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer
title_sort il-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/bccae141645e49d6828a1fe5efe66a25
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