Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction

Hepatitis B virus X protein (HBx) binds anti-apoptotic Bcl-xL through its BH3-like motif to promote viral replication. Here, the authors provide the structure of the HBx BH3-like domain and Bcl-xL, which shows an unusual mode of interaction, and identify a short peptide that inhibits HBV replication...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tian-Ying Zhang, Hong-Ying Chen, Jia-Li Cao, Hua-Long Xiong, Xiao-Bing Mo, Tian-Liang Li, Xiao-Zhen Kang, Jing-Hua Zhao, Bo Yin, Xiang Zhao, Cheng-Hao Huang, Quan Yuan, Ding Xue, Ning-Shao Xia, Y. Adam Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bccf1b6cc6fc4a3986b958df99dc247d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bccf1b6cc6fc4a3986b958df99dc247d
record_format	dspace
spelling	oai:doaj.org-article:bccf1b6cc6fc4a3986b958df99dc247d2021-12-02T16:58:27ZStructural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction10.1038/s41467-019-11173-12041-1723https://doaj.org/article/bccf1b6cc6fc4a3986b958df99dc247d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11173-1https://doaj.org/toc/2041-1723Hepatitis B virus X protein (HBx) binds anti-apoptotic Bcl-xL through its BH3-like motif to promote viral replication. Here, the authors provide the structure of the HBx BH3-like domain and Bcl-xL, which shows an unusual mode of interaction, and identify a short peptide that inhibits HBV replication in cultured human hepatic cells.Tian-Ying ZhangHong-Ying ChenJia-Li CaoHua-Long XiongXiao-Bing MoTian-Liang LiXiao-Zhen KangJing-Hua ZhaoBo YinXiang ZhaoCheng-Hao HuangQuan YuanDing XueNing-Shao XiaY. Adam YuanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tian-Ying Zhang Hong-Ying Chen Jia-Li Cao Hua-Long Xiong Xiao-Bing Mo Tian-Liang Li Xiao-Zhen Kang Jing-Hua Zhao Bo Yin Xiang Zhao Cheng-Hao Huang Quan Yuan Ding Xue Ning-Shao Xia Y. Adam Yuan Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
description	Hepatitis B virus X protein (HBx) binds anti-apoptotic Bcl-xL through its BH3-like motif to promote viral replication. Here, the authors provide the structure of the HBx BH3-like domain and Bcl-xL, which shows an unusual mode of interaction, and identify a short peptide that inhibits HBV replication in cultured human hepatic cells.
format	article
author	Tian-Ying Zhang Hong-Ying Chen Jia-Li Cao Hua-Long Xiong Xiao-Bing Mo Tian-Liang Li Xiao-Zhen Kang Jing-Hua Zhao Bo Yin Xiang Zhao Cheng-Hao Huang Quan Yuan Ding Xue Ning-Shao Xia Y. Adam Yuan
author_facet	Tian-Ying Zhang Hong-Ying Chen Jia-Li Cao Hua-Long Xiong Xiao-Bing Mo Tian-Liang Li Xiao-Zhen Kang Jing-Hua Zhao Bo Yin Xiang Zhao Cheng-Hao Huang Quan Yuan Ding Xue Ning-Shao Xia Y. Adam Yuan
author_sort	Tian-Ying Zhang
title	Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
title_short	Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
title_full	Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
title_fullStr	Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
title_full_unstemmed	Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
title_sort	structural and functional analyses of hepatitis b virus x protein bh3-like domain and bcl-xl interaction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bccf1b6cc6fc4a3986b958df99dc247d
work_keys_str_mv	AT tianyingzhang structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT hongyingchen structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT jialicao structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT hualongxiong structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT xiaobingmo structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT tianliangli structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT xiaozhenkang structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT jinghuazhao structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT boyin structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT xiangzhao structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT chenghaohuang structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT quanyuan structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT dingxue structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT ningshaoxia structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction AT yadamyuan structuralandfunctionalanalysesofhepatitisbvirusxproteinbh3likedomainandbclxlinteraction
_version_	1718382291623870464

Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction

Ejemplares similares