Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules

Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as pr...

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Autores principales:	Charlotte Rimbault, Kashyap Maruthi, Christelle Breillat, Camille Genuer, Sara Crespillo, Virginia Puente-Muñoz, Ingrid Chamma, Isabel Gauthereau, Ségolène Antoine, Coraline Thibaut, Fabienne Wong Jun Tai, Benjamin Dartigues, Dolors Grillo-Bosch, Stéphane Claverol, Christel Poujol, Daniel Choquet, Cameron D. Mackereth, Matthieu Sainlos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bccf7dc6c979424398f916ba76abb566
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spelling	oai:doaj.org-article:bccf7dc6c979424398f916ba76abb5662021-12-02T17:01:47ZEngineering selective competitors for the discrimination of highly conserved protein-protein interaction modules10.1038/s41467-019-12528-42041-1723https://doaj.org/article/bccf7dc6c979424398f916ba76abb5662019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12528-4https://doaj.org/toc/2041-1723Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as proof-of-concept.Charlotte RimbaultKashyap MaruthiChristelle BreillatCamille GenuerSara CrespilloVirginia Puente-MuñozIngrid ChammaIsabel GauthereauSégolène AntoineCoraline ThibautFabienne Wong Jun TaiBenjamin DartiguesDolors Grillo-BoschStéphane ClaverolChristel PoujolDaniel ChoquetCameron D. MackerethMatthieu SainlosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charlotte Rimbault Kashyap Maruthi Christelle Breillat Camille Genuer Sara Crespillo Virginia Puente-Muñoz Ingrid Chamma Isabel Gauthereau Ségolène Antoine Coraline Thibaut Fabienne Wong Jun Tai Benjamin Dartigues Dolors Grillo-Bosch Stéphane Claverol Christel Poujol Daniel Choquet Cameron D. Mackereth Matthieu Sainlos Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
description	Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as proof-of-concept.
format	article
author	Charlotte Rimbault Kashyap Maruthi Christelle Breillat Camille Genuer Sara Crespillo Virginia Puente-Muñoz Ingrid Chamma Isabel Gauthereau Ségolène Antoine Coraline Thibaut Fabienne Wong Jun Tai Benjamin Dartigues Dolors Grillo-Bosch Stéphane Claverol Christel Poujol Daniel Choquet Cameron D. Mackereth Matthieu Sainlos
author_facet	Charlotte Rimbault Kashyap Maruthi Christelle Breillat Camille Genuer Sara Crespillo Virginia Puente-Muñoz Ingrid Chamma Isabel Gauthereau Ségolène Antoine Coraline Thibaut Fabienne Wong Jun Tai Benjamin Dartigues Dolors Grillo-Bosch Stéphane Claverol Christel Poujol Daniel Choquet Cameron D. Mackereth Matthieu Sainlos
author_sort	Charlotte Rimbault
title	Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_short	Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_full	Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_fullStr	Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_full_unstemmed	Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_sort	engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bccf7dc6c979424398f916ba76abb566
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Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules

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