Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules

Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as pr...

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Autores principales: Charlotte Rimbault, Kashyap Maruthi, Christelle Breillat, Camille Genuer, Sara Crespillo, Virginia Puente-Muñoz, Ingrid Chamma, Isabel Gauthereau, Ségolène Antoine, Coraline Thibaut, Fabienne Wong Jun Tai, Benjamin Dartigues, Dolors Grillo-Bosch, Stéphane Claverol, Christel Poujol, Daniel Choquet, Cameron D. Mackereth, Matthieu Sainlos
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Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/bccf7dc6c979424398f916ba76abb566
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spelling oai:doaj.org-article:bccf7dc6c979424398f916ba76abb5662021-12-02T17:01:47ZEngineering selective competitors for the discrimination of highly conserved protein-protein interaction modules10.1038/s41467-019-12528-42041-1723https://doaj.org/article/bccf7dc6c979424398f916ba76abb5662019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12528-4https://doaj.org/toc/2041-1723Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as proof-of-concept.Charlotte RimbaultKashyap MaruthiChristelle BreillatCamille GenuerSara CrespilloVirginia Puente-MuñozIngrid ChammaIsabel GauthereauSégolène AntoineCoraline ThibautFabienne Wong Jun TaiBenjamin DartiguesDolors Grillo-BoschStéphane ClaverolChristel PoujolDaniel ChoquetCameron D. MackerethMatthieu SainlosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Charlotte Rimbault
Kashyap Maruthi
Christelle Breillat
Camille Genuer
Sara Crespillo
Virginia Puente-Muñoz
Ingrid Chamma
Isabel Gauthereau
Ségolène Antoine
Coraline Thibaut
Fabienne Wong Jun Tai
Benjamin Dartigues
Dolors Grillo-Bosch
Stéphane Claverol
Christel Poujol
Daniel Choquet
Cameron D. Mackereth
Matthieu Sainlos
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
description Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as proof-of-concept.
format article
author Charlotte Rimbault
Kashyap Maruthi
Christelle Breillat
Camille Genuer
Sara Crespillo
Virginia Puente-Muñoz
Ingrid Chamma
Isabel Gauthereau
Ségolène Antoine
Coraline Thibaut
Fabienne Wong Jun Tai
Benjamin Dartigues
Dolors Grillo-Bosch
Stéphane Claverol
Christel Poujol
Daniel Choquet
Cameron D. Mackereth
Matthieu Sainlos
author_facet Charlotte Rimbault
Kashyap Maruthi
Christelle Breillat
Camille Genuer
Sara Crespillo
Virginia Puente-Muñoz
Ingrid Chamma
Isabel Gauthereau
Ségolène Antoine
Coraline Thibaut
Fabienne Wong Jun Tai
Benjamin Dartigues
Dolors Grillo-Bosch
Stéphane Claverol
Christel Poujol
Daniel Choquet
Cameron D. Mackereth
Matthieu Sainlos
author_sort Charlotte Rimbault
title Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_short Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_full Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_fullStr Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_full_unstemmed Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
title_sort engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/bccf7dc6c979424398f916ba76abb566
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