Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as pr...
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Nature Portfolio
2019
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oai:doaj.org-article:bccf7dc6c979424398f916ba76abb5662021-12-02T17:01:47ZEngineering selective competitors for the discrimination of highly conserved protein-protein interaction modules10.1038/s41467-019-12528-42041-1723https://doaj.org/article/bccf7dc6c979424398f916ba76abb5662019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12528-4https://doaj.org/toc/2041-1723Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as proof-of-concept.Charlotte RimbaultKashyap MaruthiChristelle BreillatCamille GenuerSara CrespilloVirginia Puente-MuñozIngrid ChammaIsabel GauthereauSégolène AntoineCoraline ThibautFabienne Wong Jun TaiBenjamin DartiguesDolors Grillo-BoschStéphane ClaverolChristel PoujolDaniel ChoquetCameron D. MackerethMatthieu SainlosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019) |
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Science Q Charlotte Rimbault Kashyap Maruthi Christelle Breillat Camille Genuer Sara Crespillo Virginia Puente-Muñoz Ingrid Chamma Isabel Gauthereau Ségolène Antoine Coraline Thibaut Fabienne Wong Jun Tai Benjamin Dartigues Dolors Grillo-Bosch Stéphane Claverol Christel Poujol Daniel Choquet Cameron D. Mackereth Matthieu Sainlos Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules |
description |
Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as proof-of-concept. |
format |
article |
author |
Charlotte Rimbault Kashyap Maruthi Christelle Breillat Camille Genuer Sara Crespillo Virginia Puente-Muñoz Ingrid Chamma Isabel Gauthereau Ségolène Antoine Coraline Thibaut Fabienne Wong Jun Tai Benjamin Dartigues Dolors Grillo-Bosch Stéphane Claverol Christel Poujol Daniel Choquet Cameron D. Mackereth Matthieu Sainlos |
author_facet |
Charlotte Rimbault Kashyap Maruthi Christelle Breillat Camille Genuer Sara Crespillo Virginia Puente-Muñoz Ingrid Chamma Isabel Gauthereau Ségolène Antoine Coraline Thibaut Fabienne Wong Jun Tai Benjamin Dartigues Dolors Grillo-Bosch Stéphane Claverol Christel Poujol Daniel Choquet Cameron D. Mackereth Matthieu Sainlos |
author_sort |
Charlotte Rimbault |
title |
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules |
title_short |
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules |
title_full |
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules |
title_fullStr |
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules |
title_full_unstemmed |
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules |
title_sort |
engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/bccf7dc6c979424398f916ba76abb566 |
work_keys_str_mv |
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