Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Jing Yao, Yuanke Li, Xiaojing Sun, Fatima Zohra Dahmani, Hongpan Liu, Jianping Zhou State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China Abstract: In order to enhance the in vivo codelivery efficiency of gambogic acid (GA) and a...

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Autores principales:	Yao J, Li Y, Sun X, Dahmani FZ, Liu H, Zhou J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bcd028a8dc2140b582d7ab44abb41ede
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spelling	oai:doaj.org-article:bcd028a8dc2140b582d7ab44abb41ede2021-12-02T02:31:35ZNanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid1178-2013https://doaj.org/article/bcd028a8dc2140b582d7ab44abb41ede2014-07-01T00:00:00Zhttp://www.dovepress.com/nanoparticle-delivery-and-combination-therapy-of-gambogic-acid-and-all-a17552https://doaj.org/toc/1178-2013 Jing Yao, Yuanke Li, Xiaojing Sun, Fatima Zohra Dahmani, Hongpan Liu, Jianping Zhou State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China Abstract: In order to enhance the in vivo codelivery efficiency of gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanoparticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) conjugate. In this way, GA and ATRA were loaded simultaneously in a nanocarrier and codelivered into the tumor cell through HA receptor-mediated endocytosis. GA-loaded HRA nanoparticles (GA-HRA) were prepared by a dialysis method, and their physicochemical characteristics were investigated as well. GA-HRA exhibited a high drug loading capacity (31.1%), had a particle size in the range of 100–150 nm, and good biocompatibility. HRA nanoparticles were effectively internalized by MCF-7 cells and translocated into the nucleus in a time-dependent manner. The in vivo imaging analysis demonstrated that the fluorescent signals in the tumor were markedly increased with DiR-loaded nanoparticles after intravenous administration compared to free DiR solution, suggesting it has excellent tumor targeting properties. More importantly, GA-HRA exhibited excellent in vivo efficacy with dramatically reduced toxicity. In conclusion, with the assistance of HRA nanoparticles, GA and ATRA can successfully realize an effective combination chemotherapy as well as tumor-targeted delivery. Keywords: tumor targeting, nanoparticles, hyaluronic acidYao JLi YSun XDahmani FZLiu HZhou JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3313-3324 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yao J Li Y Sun X Dahmani FZ Liu H Zhou J Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
description	Jing Yao, Yuanke Li, Xiaojing Sun, Fatima Zohra Dahmani, Hongpan Liu, Jianping Zhou State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China Abstract: In order to enhance the in vivo codelivery efficiency of gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanoparticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) conjugate. In this way, GA and ATRA were loaded simultaneously in a nanocarrier and codelivered into the tumor cell through HA receptor-mediated endocytosis. GA-loaded HRA nanoparticles (GA-HRA) were prepared by a dialysis method, and their physicochemical characteristics were investigated as well. GA-HRA exhibited a high drug loading capacity (31.1%), had a particle size in the range of 100–150 nm, and good biocompatibility. HRA nanoparticles were effectively internalized by MCF-7 cells and translocated into the nucleus in a time-dependent manner. The in vivo imaging analysis demonstrated that the fluorescent signals in the tumor were markedly increased with DiR-loaded nanoparticles after intravenous administration compared to free DiR solution, suggesting it has excellent tumor targeting properties. More importantly, GA-HRA exhibited excellent in vivo efficacy with dramatically reduced toxicity. In conclusion, with the assistance of HRA nanoparticles, GA and ATRA can successfully realize an effective combination chemotherapy as well as tumor-targeted delivery. Keywords: tumor targeting, nanoparticles, hyaluronic acid
format	article
author	Yao J Li Y Sun X Dahmani FZ Liu H Zhou J
author_facet	Yao J Li Y Sun X Dahmani FZ Liu H Zhou J
author_sort	Yao J
title	Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
title_short	Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
title_full	Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
title_fullStr	Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
title_full_unstemmed	Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
title_sort	nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/bcd028a8dc2140b582d7ab44abb41ede
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Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

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