Association Between Systemic Immune-Inflammation Index and Diabetic Depression

Jie Wang,1 Depu Zhou,1 Zhijuan Dai,2 Xiaokun Li1 1Department of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of China; 2Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic o...

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Autores principales:	Wang J, Zhou D, Dai Z, Li X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	systemic immune-inflammation index depressive symptoms diabetes mellitus nhanes Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/bcd173b117ea40c5b88380d27ed772e9
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spelling	oai:doaj.org-article:bcd173b117ea40c5b88380d27ed772e92021-12-02T14:01:49ZAssociation Between Systemic Immune-Inflammation Index and Diabetic Depression1178-1998https://doaj.org/article/bcd173b117ea40c5b88380d27ed772e92021-01-01T00:00:00Zhttps://www.dovepress.com/association-between-systemic-immune-inflammation-index-and-diabetic-de-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jie Wang,1 Depu Zhou,1 Zhijuan Dai,2 Xiaokun Li1 1Department of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of China; 2Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Xiaokun LiDepartment of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of ChinaEmail profxiaokunli@163.comBackground: Depression is highly prevalent in patients with diabetes mellitus (DM). Diabetic depression has been shown to be associated with low-grade systemic inflammation. In recent years, the systemic immune-inflammation (SII) index has been developed as an integrated and novel inflammatory indicator. The aims of this study were to investigate the relationship between diabetic depression and SII levels, adjusting for a wide range of potential confounding factors, to examine the potential of SII in predicting diabetic depression.Methods: The present cross-sectional study was conducted among adults with DM in the National Health and Nutrition Examination Survey between 2009 and 2016, the SII level was calculated as the platelet counts × neutrophil counts/lymphocyte counts. Patient Health Questionnaire‐9 was used to measure depression in patients with DM. Multivariable logistic regression and propensity score-matched analysis were used to analyze the association between SII levels and depression.Results: A total of 2566 patients with DM were included in the study, of which 370 (13.3%) were diagnosed with depression. Multivariable logistic regression showed that high SII level was an independent risk factor for diabetic depression (OR = 1.347, 95% CI: 1.031– 1.760, P = 0.02882) after adjusting for covariates. The relationship between SII and diabetic depression was further verified by propensity score-matched analysis.Conclusion: Our data suggest that SII is a risk factor for depression in patients with DM. The SII may be an easily accessible and cost-effective strategy for identifying depression in patients with DM. More studies are warranted to further analyze the role of SII in depression in diabetic patients.Keywords: systemic immune-inflammation index, depressive symptoms, diabetes mellitus, NHANESWang JZhou DDai ZLi XDove Medical Pressarticlesystemic immune-inflammation indexdepressive symptomsdiabetes mellitusnhanesGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 97-105 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic immune-inflammation index depressive symptoms diabetes mellitus nhanes Geriatrics RC952-954.6
spellingShingle	systemic immune-inflammation index depressive symptoms diabetes mellitus nhanes Geriatrics RC952-954.6 Wang J Zhou D Dai Z Li X Association Between Systemic Immune-Inflammation Index and Diabetic Depression
description	Jie Wang,1 Depu Zhou,1 Zhijuan Dai,2 Xiaokun Li1 1Department of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of China; 2Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Xiaokun LiDepartment of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of ChinaEmail profxiaokunli@163.comBackground: Depression is highly prevalent in patients with diabetes mellitus (DM). Diabetic depression has been shown to be associated with low-grade systemic inflammation. In recent years, the systemic immune-inflammation (SII) index has been developed as an integrated and novel inflammatory indicator. The aims of this study were to investigate the relationship between diabetic depression and SII levels, adjusting for a wide range of potential confounding factors, to examine the potential of SII in predicting diabetic depression.Methods: The present cross-sectional study was conducted among adults with DM in the National Health and Nutrition Examination Survey between 2009 and 2016, the SII level was calculated as the platelet counts × neutrophil counts/lymphocyte counts. Patient Health Questionnaire‐9 was used to measure depression in patients with DM. Multivariable logistic regression and propensity score-matched analysis were used to analyze the association between SII levels and depression.Results: A total of 2566 patients with DM were included in the study, of which 370 (13.3%) were diagnosed with depression. Multivariable logistic regression showed that high SII level was an independent risk factor for diabetic depression (OR = 1.347, 95% CI: 1.031– 1.760, P = 0.02882) after adjusting for covariates. The relationship between SII and diabetic depression was further verified by propensity score-matched analysis.Conclusion: Our data suggest that SII is a risk factor for depression in patients with DM. The SII may be an easily accessible and cost-effective strategy for identifying depression in patients with DM. More studies are warranted to further analyze the role of SII in depression in diabetic patients.Keywords: systemic immune-inflammation index, depressive symptoms, diabetes mellitus, NHANES
format	article
author	Wang J Zhou D Dai Z Li X
author_facet	Wang J Zhou D Dai Z Li X
author_sort	Wang J
title	Association Between Systemic Immune-Inflammation Index and Diabetic Depression
title_short	Association Between Systemic Immune-Inflammation Index and Diabetic Depression
title_full	Association Between Systemic Immune-Inflammation Index and Diabetic Depression
title_fullStr	Association Between Systemic Immune-Inflammation Index and Diabetic Depression
title_full_unstemmed	Association Between Systemic Immune-Inflammation Index and Diabetic Depression
title_sort	association between systemic immune-inflammation index and diabetic depression
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/bcd173b117ea40c5b88380d27ed772e9
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Association Between Systemic Immune-Inflammation Index and Diabetic Depression

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