A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division

Owa and Dynlacht employ an auxin-inducible degron system to achieve acute degradation of CENP-E. As a result, the authors reveal a kinetochore-independent role for CENP-E that removes PCM1 from centrosomes in interphase, with implications in microcephaly.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mikito Owa, Brian Dynlacht
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bcd1f4561dfc4180bc3ace317b753601
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bcd1f4561dfc4180bc3ace317b753601
record_format	dspace
spelling	oai:doaj.org-article:bcd1f4561dfc4180bc3ace317b7536012021-12-02T11:39:19ZA non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division10.1038/s42003-021-01861-42399-3642https://doaj.org/article/bcd1f4561dfc4180bc3ace317b7536012021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01861-4https://doaj.org/toc/2399-3642Owa and Dynlacht employ an auxin-inducible degron system to achieve acute degradation of CENP-E. As a result, the authors reveal a kinetochore-independent role for CENP-E that removes PCM1 from centrosomes in interphase, with implications in microcephaly.Mikito OwaBrian DynlachtNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mikito Owa Brian Dynlacht A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
description	Owa and Dynlacht employ an auxin-inducible degron system to achieve acute degradation of CENP-E. As a result, the authors reveal a kinetochore-independent role for CENP-E that removes PCM1 from centrosomes in interphase, with implications in microcephaly.
format	article
author	Mikito Owa Brian Dynlacht
author_facet	Mikito Owa Brian Dynlacht
author_sort	Mikito Owa
title	A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
title_short	A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
title_full	A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
title_fullStr	A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
title_full_unstemmed	A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
title_sort	non-canonical function for centromere-associated protein-e controls centrosome integrity and orientation of cell division
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bcd1f4561dfc4180bc3ace317b753601
work_keys_str_mv	AT mikitoowa anoncanonicalfunctionforcentromereassociatedproteinecontrolscentrosomeintegrityandorientationofcelldivision AT briandynlacht anoncanonicalfunctionforcentromereassociatedproteinecontrolscentrosomeintegrityandorientationofcelldivision AT mikitoowa noncanonicalfunctionforcentromereassociatedproteinecontrolscentrosomeintegrityandorientationofcelldivision AT briandynlacht noncanonicalfunctionforcentromereassociatedproteinecontrolscentrosomeintegrityandorientationofcelldivision
_version_	1718395723500748800

A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division

Ejemplares similares