A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division

Owa and Dynlacht employ an auxin-inducible degron system to achieve acute degradation of CENP-E. As a result, the authors reveal a kinetochore-independent role for CENP-E that removes PCM1 from centrosomes in interphase, with implications in microcephaly.

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Detalles Bibliográficos
Autores principales: Mikito Owa, Brian Dynlacht
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bcd1f4561dfc4180bc3ace317b753601
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