Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia

Abstract This study aimed to test how an 8-week training using computerized cognitive remediation therapy (CCRT) would modify resting brain functional activity and improve cognitive function in patients with schizophrenia. Twenty-seven patients with schizophrenia were recruited and randomized into t...

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Autores principales:	Fengmei Fan, Yizhuang Zou, Yunlong Tan, L. Elliot Hong, Shuping Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bcd5d3e328e54137950091a8397df5b5
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spelling	oai:doaj.org-article:bcd5d3e328e54137950091a8397df5b52021-12-02T16:06:20ZComputerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia10.1038/s41598-017-04829-92045-2322https://doaj.org/article/bcd5d3e328e54137950091a8397df5b52017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04829-9https://doaj.org/toc/2045-2322Abstract This study aimed to test how an 8-week training using computerized cognitive remediation therapy (CCRT) would modify resting brain functional activity and improve cognitive function in patients with schizophrenia. Twenty-seven patients with schizophrenia were recruited and randomized into two groups: CCRT or treatment-as-usual (TAU). The CCRT group received 40 sessions of computerized cognitive training over an eight-week period. There was a significant treatment group × time interaction on the processing speed (trail making test: F = 8.14, P = 0.01) and a trend in problem solving (mazes test: P = 0.06). Post-hoc tests showed that CCRT but not TAU significantly improved scores from baseline to end-of-treatment on these two cognitive assessments. For the resting brain functional activity, significant group × time interaction effect was found in the medial prefrontal cortex (mPFC)/anterior cingulate cortex (ACC) and brainstem pons region. Post-hoc tests showed that there was significant increased activity in the mPFC/ACC in CCRT but not TAU group. In this small sample study, computerized cognitive remediation therapy is shown to enhance mPFC/ACC activity even at resting state and improve cognitive function in patients with schizophrenia. If replicated, this community and clinic accessible therapy may assist cognitive remediation effort for people with schizophrenia.Fengmei FanYizhuang ZouYunlong TanL. Elliot HongShuping TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fengmei Fan Yizhuang Zou Yunlong Tan L. Elliot Hong Shuping Tan Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia
description	Abstract This study aimed to test how an 8-week training using computerized cognitive remediation therapy (CCRT) would modify resting brain functional activity and improve cognitive function in patients with schizophrenia. Twenty-seven patients with schizophrenia were recruited and randomized into two groups: CCRT or treatment-as-usual (TAU). The CCRT group received 40 sessions of computerized cognitive training over an eight-week period. There was a significant treatment group × time interaction on the processing speed (trail making test: F = 8.14, P = 0.01) and a trend in problem solving (mazes test: P = 0.06). Post-hoc tests showed that CCRT but not TAU significantly improved scores from baseline to end-of-treatment on these two cognitive assessments. For the resting brain functional activity, significant group × time interaction effect was found in the medial prefrontal cortex (mPFC)/anterior cingulate cortex (ACC) and brainstem pons region. Post-hoc tests showed that there was significant increased activity in the mPFC/ACC in CCRT but not TAU group. In this small sample study, computerized cognitive remediation therapy is shown to enhance mPFC/ACC activity even at resting state and improve cognitive function in patients with schizophrenia. If replicated, this community and clinic accessible therapy may assist cognitive remediation effort for people with schizophrenia.
format	article
author	Fengmei Fan Yizhuang Zou Yunlong Tan L. Elliot Hong Shuping Tan
author_facet	Fengmei Fan Yizhuang Zou Yunlong Tan L. Elliot Hong Shuping Tan
author_sort	Fengmei Fan
title	Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia
title_short	Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia
title_full	Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia
title_fullStr	Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia
title_full_unstemmed	Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia
title_sort	computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bcd5d3e328e54137950091a8397df5b5
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Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia

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