IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.

<h4>Background</h4>The clinical utility of testing for antiphospholipid antibodies (aPL) of IgA isotype remains controversial.<h4>Methodology/principal findings</h4>To address this issue, we reasoned that if IgA aPL contribute to the clinical manifestations of the antiphospho...

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Autores principales:	Nadera J Sweiss, Ronghai Bo, Reena Kapadia, Deborah Manst, Farzan Mahmood, Tara Adhikari, Suncica Volkov, Maria Badaracco, Mary Smaron, Anthony Chang, Joseph Baron, Jerrold S Levine
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bcd6a91bee5d4518a6fbce993519e1b8
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spelling	oai:doaj.org-article:bcd6a91bee5d4518a6fbce993519e1b82021-11-18T06:35:53ZIgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.1932-620310.1371/journal.pone.0012280https://doaj.org/article/bcd6a91bee5d4518a6fbce993519e1b82010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808864/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The clinical utility of testing for antiphospholipid antibodies (aPL) of IgA isotype remains controversial.<h4>Methodology/principal findings</h4>To address this issue, we reasoned that if IgA aPL contribute to the clinical manifestations of the antiphospholipid syndrome, then an association with thromboembolic events should manifest in patients whose only aPL is of IgA isotype. We performed a retrospective chart review of 56 patients (31 with systemic lupus erythematosus [SLE] and 25 without SLE) whose only positive aPL was IgA anti-beta2-glycoprotein I (isolated IgA anti-beta2GPI) and compared their clinical features with 56 individually matched control patients without any aPL. Patients with isolated IgA anti-beta2GPI had a significantly increased number of thromboembolic events, as compared to controls. When patients were stratified into those with and without SLE, the association between isolated IgA anti-beta2GPI and thromboembolic events persisted for patients with SLE, but was lost for those without SLE. Titers of IgA anti-beta2GPI were significantly higher in SLE patients who suffered a thromboembolic event. Among patients with isolated IgA anti-beta2GPI, there was an increased prevalence of diseases or morbidities involving organs of mucosal immunity (i.e., gastrointestinal system, pulmonary system, and skin).<h4>Conclusions/significance</h4>The presence of isolated IgA anti-beta2GPI is associated with an increased risk of thromboembolic events, especially among patients with SLE. IgA anti-beta2GPI is associated with an increased prevalence of morbidities involving organs of mucosal immunity.Nadera J SweissRonghai BoReena KapadiaDeborah ManstFarzan MahmoodTara AdhikariSuncica VolkovMaria BadaraccoMary SmaronAnthony ChangJoseph BaronJerrold S LevinePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e12280 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadera J Sweiss Ronghai Bo Reena Kapadia Deborah Manst Farzan Mahmood Tara Adhikari Suncica Volkov Maria Badaracco Mary Smaron Anthony Chang Joseph Baron Jerrold S Levine IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.
description	<h4>Background</h4>The clinical utility of testing for antiphospholipid antibodies (aPL) of IgA isotype remains controversial.<h4>Methodology/principal findings</h4>To address this issue, we reasoned that if IgA aPL contribute to the clinical manifestations of the antiphospholipid syndrome, then an association with thromboembolic events should manifest in patients whose only aPL is of IgA isotype. We performed a retrospective chart review of 56 patients (31 with systemic lupus erythematosus [SLE] and 25 without SLE) whose only positive aPL was IgA anti-beta2-glycoprotein I (isolated IgA anti-beta2GPI) and compared their clinical features with 56 individually matched control patients without any aPL. Patients with isolated IgA anti-beta2GPI had a significantly increased number of thromboembolic events, as compared to controls. When patients were stratified into those with and without SLE, the association between isolated IgA anti-beta2GPI and thromboembolic events persisted for patients with SLE, but was lost for those without SLE. Titers of IgA anti-beta2GPI were significantly higher in SLE patients who suffered a thromboembolic event. Among patients with isolated IgA anti-beta2GPI, there was an increased prevalence of diseases or morbidities involving organs of mucosal immunity (i.e., gastrointestinal system, pulmonary system, and skin).<h4>Conclusions/significance</h4>The presence of isolated IgA anti-beta2GPI is associated with an increased risk of thromboembolic events, especially among patients with SLE. IgA anti-beta2GPI is associated with an increased prevalence of morbidities involving organs of mucosal immunity.
format	article
author	Nadera J Sweiss Ronghai Bo Reena Kapadia Deborah Manst Farzan Mahmood Tara Adhikari Suncica Volkov Maria Badaracco Mary Smaron Anthony Chang Joseph Baron Jerrold S Levine
author_facet	Nadera J Sweiss Ronghai Bo Reena Kapadia Deborah Manst Farzan Mahmood Tara Adhikari Suncica Volkov Maria Badaracco Mary Smaron Anthony Chang Joseph Baron Jerrold S Levine
author_sort	Nadera J Sweiss
title	IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.
title_short	IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.
title_full	IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.
title_fullStr	IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.
title_full_unstemmed	IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.
title_sort	iga anti-beta2-glycoprotein i autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/bcd6a91bee5d4518a6fbce993519e1b8
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IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.

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