Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties

Abstract Antimicrobial peptides have attracted attention as alternatives to conventional antibiotics. Previously, a novel antimicrobial peptide, melectin, consisting of 18 amino acids was isolated from the venom of a bee, Melecta albifrons. Here, we investigated the antibacterial activity of melecti...

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Autores principales:	Su Jin Ko, Eunji Park, Alina Asandei, Jee-Young Choi, Seung-Chul Lee, Chang Ho Seo, Tudor Luchian, Yoonkyung Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bcd81e0dfe3d49aa8b83f3167750b21b
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spelling	oai:doaj.org-article:bcd81e0dfe3d49aa8b83f3167750b21b2021-12-02T17:45:21ZBee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties10.1038/s41598-020-66995-72045-2322https://doaj.org/article/bcd81e0dfe3d49aa8b83f3167750b21b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66995-7https://doaj.org/toc/2045-2322Abstract Antimicrobial peptides have attracted attention as alternatives to conventional antibiotics. Previously, a novel antimicrobial peptide, melectin, consisting of 18 amino acids was isolated from the venom of a bee, Melecta albifrons. Here, we investigated the antibacterial activity of melectin against drug-resistant bacteria. Melectin showed broad-spectrum antimicrobial activity but low cytotoxicity and no hemolytic activity. Melectin maintained its antimicrobial activity at physiological salt concentrations. Melectin is an α-helical structure that binds to the bacterial membrane via electrostatic interactions and kills bacteria in a short time by bacterial membrane targeting. Collectively, our results suggest that melectin has antibacterial activity and anti-inflammatory activity.Su Jin KoEunji ParkAlina AsandeiJee-Young ChoiSeung-Chul LeeChang Ho SeoTudor LuchianYoonkyung ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Su Jin Ko Eunji Park Alina Asandei Jee-Young Choi Seung-Chul Lee Chang Ho Seo Tudor Luchian Yoonkyung Park Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
description	Abstract Antimicrobial peptides have attracted attention as alternatives to conventional antibiotics. Previously, a novel antimicrobial peptide, melectin, consisting of 18 amino acids was isolated from the venom of a bee, Melecta albifrons. Here, we investigated the antibacterial activity of melectin against drug-resistant bacteria. Melectin showed broad-spectrum antimicrobial activity but low cytotoxicity and no hemolytic activity. Melectin maintained its antimicrobial activity at physiological salt concentrations. Melectin is an α-helical structure that binds to the bacterial membrane via electrostatic interactions and kills bacteria in a short time by bacterial membrane targeting. Collectively, our results suggest that melectin has antibacterial activity and anti-inflammatory activity.
format	article
author	Su Jin Ko Eunji Park Alina Asandei Jee-Young Choi Seung-Chul Lee Chang Ho Seo Tudor Luchian Yoonkyung Park
author_facet	Su Jin Ko Eunji Park Alina Asandei Jee-Young Choi Seung-Chul Lee Chang Ho Seo Tudor Luchian Yoonkyung Park
author_sort	Su Jin Ko
title	Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
title_short	Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
title_full	Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
title_fullStr	Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
title_full_unstemmed	Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
title_sort	bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bcd81e0dfe3d49aa8b83f3167750b21b
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Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties

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