A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity and myeloid, erythroid, and megakaryocytic lineage d...

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Autores principales:	Yuanbin Song, Anthony Rongvaux, Ashley Taylor, Tingting Jiang, Toma Tebaldi, Kunthavai Balasubramanian, Arun Bagale, Yunus Kasim Terzi, Rana Gbyli, Xiaman Wang, Xiaoying Fu, Yimeng Gao, Jun Zhao, Nikolai Podoltsev, Mina Xu, Natalia Neparidze, Ellice Wong, Richard Torres, Emanuela M. Bruscia, Yuval Kluger, Markus G. Manz, Richard A. Flavell, Stephanie Halene
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bcd8edb0cae9459b894b2cf494c1bf39
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spelling	oai:doaj.org-article:bcd8edb0cae9459b894b2cf494c1bf392021-12-02T14:35:56ZA highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies10.1038/s41467-018-08166-x2041-1723https://doaj.org/article/bcd8edb0cae9459b894b2cf494c1bf392019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08166-xhttps://doaj.org/toc/2041-1723Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity and myeloid, erythroid, and megakaryocytic lineage dysplasia.Yuanbin SongAnthony RongvauxAshley TaylorTingting JiangToma TebaldiKunthavai BalasubramanianArun BagaleYunus Kasim TerziRana GbyliXiaman WangXiaoying FuYimeng GaoJun ZhaoNikolai PodoltsevMina XuNatalia NeparidzeEllice WongRichard TorresEmanuela M. BrusciaYuval KlugerMarkus G. ManzRichard A. FlavellStephanie HaleneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanbin Song Anthony Rongvaux Ashley Taylor Tingting Jiang Toma Tebaldi Kunthavai Balasubramanian Arun Bagale Yunus Kasim Terzi Rana Gbyli Xiaman Wang Xiaoying Fu Yimeng Gao Jun Zhao Nikolai Podoltsev Mina Xu Natalia Neparidze Ellice Wong Richard Torres Emanuela M. Bruscia Yuval Kluger Markus G. Manz Richard A. Flavell Stephanie Halene A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
description	Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity and myeloid, erythroid, and megakaryocytic lineage dysplasia.
format	article
author	Yuanbin Song Anthony Rongvaux Ashley Taylor Tingting Jiang Toma Tebaldi Kunthavai Balasubramanian Arun Bagale Yunus Kasim Terzi Rana Gbyli Xiaman Wang Xiaoying Fu Yimeng Gao Jun Zhao Nikolai Podoltsev Mina Xu Natalia Neparidze Ellice Wong Richard Torres Emanuela M. Bruscia Yuval Kluger Markus G. Manz Richard A. Flavell Stephanie Halene
author_facet	Yuanbin Song Anthony Rongvaux Ashley Taylor Tingting Jiang Toma Tebaldi Kunthavai Balasubramanian Arun Bagale Yunus Kasim Terzi Rana Gbyli Xiaman Wang Xiaoying Fu Yimeng Gao Jun Zhao Nikolai Podoltsev Mina Xu Natalia Neparidze Ellice Wong Richard Torres Emanuela M. Bruscia Yuval Kluger Markus G. Manz Richard A. Flavell Stephanie Halene
author_sort	Yuanbin Song
title	A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
title_short	A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
title_full	A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
title_fullStr	A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
title_full_unstemmed	A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
title_sort	highly efficient and faithful mds patient-derived xenotransplantation model for pre-clinical studies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bcd8edb0cae9459b894b2cf494c1bf39
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A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

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