Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synapt...

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Autores principales:	Ido Badash, Patricia M. Quiñones, Kevin J. Oghalai, Juemei Wang, Christopher G. Lui, Frank Macias-Escriva, Brian E. Applegate, John S. Oghalai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hidden hearing loss acoustic trauma ribbon synapse cochlear synaptopathy endolymphatic hydrops Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bcda5e59e06c40df8d45b20139c06a59
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spelling	oai:doaj.org-article:bcda5e59e06c40df8d45b20139c06a592021-11-05T07:58:34ZEndolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure2296-634X10.3389/fcell.2021.747870https://doaj.org/article/bcda5e59e06c40df8d45b20139c06a592021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.747870/fullhttps://doaj.org/toc/2296-634XAfter acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synaptopathy and found that they also developed a build-up of endolymph, termed endolymphatic hydrops. In this study, we used optical coherence tomography to measure endolymph volume in live CBA/CaJ mice exposed to various noise intensities. We quantified the number of synaptic ribbons and postsynaptic densities under the inner hair cells 1 week after noise exposure to determine if they correlated with acute changes in endolymph volume measured in the hours after the noise exposure. After 2 h of noise at an intensity of 95 dB SPL or below, both endolymph volume and synaptic counts remained normal. After exposure to 2 h of 100 dB SPL noise, mice developed endolymphatic hydrops and had reduced synaptic counts in the basal and middle regions of the cochlea. Furthermore, round-window application of hypertonic saline reduced the degree of endolymphatic hydrops that developed after 100 dB SPL noise exposure and partially prevented the reduction in synaptic counts in the cochlear base. Taken together, these results indicate that endolymphatic hydrops correlates with noise-induced cochlear synaptopathy, suggesting that these two pathologic findings have a common mechanistic basis.Ido BadashPatricia M. QuiñonesKevin J. OghalaiJuemei WangChristopher G. LuiFrank Macias-EscrivaBrian E. ApplegateBrian E. ApplegateJohn S. OghalaiJohn S. OghalaiFrontiers Media S.A.articlehidden hearing lossacoustic traumaribbon synapsecochlear synaptopathyendolymphatic hydropsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hidden hearing loss acoustic trauma ribbon synapse cochlear synaptopathy endolymphatic hydrops Biology (General) QH301-705.5
spellingShingle	hidden hearing loss acoustic trauma ribbon synapse cochlear synaptopathy endolymphatic hydrops Biology (General) QH301-705.5 Ido Badash Patricia M. Quiñones Kevin J. Oghalai Juemei Wang Christopher G. Lui Frank Macias-Escriva Brian E. Applegate Brian E. Applegate John S. Oghalai John S. Oghalai Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
description	After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synaptopathy and found that they also developed a build-up of endolymph, termed endolymphatic hydrops. In this study, we used optical coherence tomography to measure endolymph volume in live CBA/CaJ mice exposed to various noise intensities. We quantified the number of synaptic ribbons and postsynaptic densities under the inner hair cells 1 week after noise exposure to determine if they correlated with acute changes in endolymph volume measured in the hours after the noise exposure. After 2 h of noise at an intensity of 95 dB SPL or below, both endolymph volume and synaptic counts remained normal. After exposure to 2 h of 100 dB SPL noise, mice developed endolymphatic hydrops and had reduced synaptic counts in the basal and middle regions of the cochlea. Furthermore, round-window application of hypertonic saline reduced the degree of endolymphatic hydrops that developed after 100 dB SPL noise exposure and partially prevented the reduction in synaptic counts in the cochlear base. Taken together, these results indicate that endolymphatic hydrops correlates with noise-induced cochlear synaptopathy, suggesting that these two pathologic findings have a common mechanistic basis.
format	article
author	Ido Badash Patricia M. Quiñones Kevin J. Oghalai Juemei Wang Christopher G. Lui Frank Macias-Escriva Brian E. Applegate Brian E. Applegate John S. Oghalai John S. Oghalai
author_facet	Ido Badash Patricia M. Quiñones Kevin J. Oghalai Juemei Wang Christopher G. Lui Frank Macias-Escriva Brian E. Applegate Brian E. Applegate John S. Oghalai John S. Oghalai
author_sort	Ido Badash
title	Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
title_short	Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
title_full	Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
title_fullStr	Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
title_full_unstemmed	Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
title_sort	endolymphatic hydrops is a marker of synaptopathy following traumatic noise exposure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bcda5e59e06c40df8d45b20139c06a59
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_version_	1718444495089958912

Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

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