p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.

<h4>Background</h4>The tumor suppressor p53 is an important regulator that controls various cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 facilitates cell differentiation, whereas others claim that it suppresses differentiation. Therefore...

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Autores principales:	Alina Molchadsky, Igor Shats, Naomi Goldfinger, Meirav Pevsner-Fischer, Melissa Olson, Ariel Rinon, Eldad Tzahor, Guillermina Lozano, Dov Zipori, Rachel Sarig, Varda Rotter
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bcdc953a1ba5450da516686ffe126f1d
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spelling	oai:doaj.org-article:bcdc953a1ba5450da516686ffe126f1d2021-11-25T06:18:33Zp53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.1932-620310.1371/journal.pone.0003707https://doaj.org/article/bcdc953a1ba5450da516686ffe126f1d2008-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19002260/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The tumor suppressor p53 is an important regulator that controls various cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 facilitates cell differentiation, whereas others claim that it suppresses differentiation. Therefore, it is critical to evaluate whether this inconsistency represents an authentic differential p53 activity manifested in the various differentiation programs.<h4>Methodology/principal findings</h4>To clarify this important issue, we conducted a comparative study of several mesenchymal differentiation programs. The effects of p53 knockdown or enhanced activity were analyzed in mouse and human mesenchymal cells, representing various stages of several differentiation programs. We found that p53 down-regulated the expression of master differentiation-inducing transcription factors, thereby inhibiting osteogenic, adipogenic and smooth muscle differentiation of multiple mesenchymal cell types. In contrast, p53 is essential for skeletal muscle differentiation and osteogenic re-programming of skeletal muscle committed cells.<h4>Conclusions</h4>These comparative studies suggest that, depending on the specific cell type and the specific differentiation program, p53 may exert a positive or a negative effect, and thus can be referred as a "guardian of differentiation" at large.Alina MolchadskyIgor ShatsNaomi GoldfingerMeirav Pevsner-FischerMelissa OlsonAriel RinonEldad TzahorGuillermina LozanoDov ZiporiRachel SarigVarda RotterPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 11, p e3707 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alina Molchadsky Igor Shats Naomi Goldfinger Meirav Pevsner-Fischer Melissa Olson Ariel Rinon Eldad Tzahor Guillermina Lozano Dov Zipori Rachel Sarig Varda Rotter p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
description	<h4>Background</h4>The tumor suppressor p53 is an important regulator that controls various cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 facilitates cell differentiation, whereas others claim that it suppresses differentiation. Therefore, it is critical to evaluate whether this inconsistency represents an authentic differential p53 activity manifested in the various differentiation programs.<h4>Methodology/principal findings</h4>To clarify this important issue, we conducted a comparative study of several mesenchymal differentiation programs. The effects of p53 knockdown or enhanced activity were analyzed in mouse and human mesenchymal cells, representing various stages of several differentiation programs. We found that p53 down-regulated the expression of master differentiation-inducing transcription factors, thereby inhibiting osteogenic, adipogenic and smooth muscle differentiation of multiple mesenchymal cell types. In contrast, p53 is essential for skeletal muscle differentiation and osteogenic re-programming of skeletal muscle committed cells.<h4>Conclusions</h4>These comparative studies suggest that, depending on the specific cell type and the specific differentiation program, p53 may exert a positive or a negative effect, and thus can be referred as a "guardian of differentiation" at large.
format	article
author	Alina Molchadsky Igor Shats Naomi Goldfinger Meirav Pevsner-Fischer Melissa Olson Ariel Rinon Eldad Tzahor Guillermina Lozano Dov Zipori Rachel Sarig Varda Rotter
author_facet	Alina Molchadsky Igor Shats Naomi Goldfinger Meirav Pevsner-Fischer Melissa Olson Ariel Rinon Eldad Tzahor Guillermina Lozano Dov Zipori Rachel Sarig Varda Rotter
author_sort	Alina Molchadsky
title	p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
title_short	p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
title_full	p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
title_fullStr	p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
title_full_unstemmed	p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
title_sort	p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/bcdc953a1ba5450da516686ffe126f1d
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p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.

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