Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion

c-Kit receptor–Kit ligand complex signaling is known to activate c-Kit and is essential for tissue development. Here, Buono et al. show that membrane-bound KitL signaling induces proliferation via CAML-Akt-CREB pathway activation, establishing a role for bidirectional signaling in tissue expansion....

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Autores principales:	Mario Buono, Marie-Laëtitia Thézénas, Alessandro Ceroni, Roman Fischer, Claus Nerlov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bcdccb1f096148578c444773d7337813
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spelling	oai:doaj.org-article:bcdccb1f096148578c444773d73378132021-12-02T15:34:43ZBi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion10.1038/s41467-018-07024-02041-1723https://doaj.org/article/bcdccb1f096148578c444773d73378132018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07024-0https://doaj.org/toc/2041-1723c-Kit receptor–Kit ligand complex signaling is known to activate c-Kit and is essential for tissue development. Here, Buono et al. show that membrane-bound KitL signaling induces proliferation via CAML-Akt-CREB pathway activation, establishing a role for bidirectional signaling in tissue expansion.Mario BuonoMarie-Laëtitia ThézénasAlessandro CeroniRoman FischerClaus NerlovNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mario Buono Marie-Laëtitia Thézénas Alessandro Ceroni Roman Fischer Claus Nerlov Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion
description	c-Kit receptor–Kit ligand complex signaling is known to activate c-Kit and is essential for tissue development. Here, Buono et al. show that membrane-bound KitL signaling induces proliferation via CAML-Akt-CREB pathway activation, establishing a role for bidirectional signaling in tissue expansion.
format	article
author	Mario Buono Marie-Laëtitia Thézénas Alessandro Ceroni Roman Fischer Claus Nerlov
author_facet	Mario Buono Marie-Laëtitia Thézénas Alessandro Ceroni Roman Fischer Claus Nerlov
author_sort	Mario Buono
title	Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion
title_short	Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion
title_full	Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion
title_fullStr	Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion
title_full_unstemmed	Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion
title_sort	bi-directional signaling by membrane-bound kitl induces proliferation and coordinates thymic endothelial cell and thymocyte expansion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bcdccb1f096148578c444773d7337813
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Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion

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