Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload

Background: Beta-thalassemia syndromes are a set of hereditary blood disorders marked by a deficiency of beta-globin chain synthesis, resultant in decrease hemoglobin in red blood cells [RBC], anemia, and a reduced RBC production Aim of the work: To evaluate glycometabolic and liver function in case...

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Autores principales:	Basma Matar, Magdy Sakr, Lotfy Alsehaimy, Hesham Abd al-samee
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	β thalassemia major (tm) serum insulin glucose iron overload Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bcdd71df38ec4889bfe1c1ffeadfd5ac
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spelling	oai:doaj.org-article:bcdd71df38ec4889bfe1c1ffeadfd5ac2021-12-02T14:10:53ZEvaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload2636-41742682-378010.21608/ijma.2020.43776.1179https://doaj.org/article/bcdd71df38ec4889bfe1c1ffeadfd5ac2021-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_125767_6bbed27b2f05315584a44effb03d181c.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Beta-thalassemia syndromes are a set of hereditary blood disorders marked by a deficiency of beta-globin chain synthesis, resultant in decrease hemoglobin in red blood cells [RBC], anemia, and a reduced RBC production Aim of the work: To evaluate glycometabolic and liver function in cases with β-thalassemia major and their correlation with serum iron and ferritin Patients and methods: This was a case-control study that was performed in the pediatric department of Al-Azher University Hospital in Damietta from June 2018 to June 2019. Fasting serum glucose, insulin, and liver enzymes were assessed for 48 cases and 40 ordinary controls. Serum iron and ferritin were recorded as an indicator of iron overload Results: Fasting serum insulin, alanine transaminase [ALT] levels, aspartate transaminase [AST] levels were significantly high in thalassemia major [TM] cases than in the control group [p Conclusion: The kids with β-TM have a high glycemic disorders incidence rate, may be because of the insulin resistance due to the amplified iron burden.Basma MatarMagdy SakrLotfy AlsehaimyHesham Abd al-sameeAl-Azhar University, Faculty of Medicine (Damietta)articleβ thalassemia major (tm)serum insulinglucoseiron overloadMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 1, Pp 1088-1096 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	β thalassemia major (tm) serum insulin glucose iron overload Medicine (General) R5-920
spellingShingle	β thalassemia major (tm) serum insulin glucose iron overload Medicine (General) R5-920 Basma Matar Magdy Sakr Lotfy Alsehaimy Hesham Abd al-samee Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload
description	Background: Beta-thalassemia syndromes are a set of hereditary blood disorders marked by a deficiency of beta-globin chain synthesis, resultant in decrease hemoglobin in red blood cells [RBC], anemia, and a reduced RBC production Aim of the work: To evaluate glycometabolic and liver function in cases with β-thalassemia major and their correlation with serum iron and ferritin Patients and methods: This was a case-control study that was performed in the pediatric department of Al-Azher University Hospital in Damietta from June 2018 to June 2019. Fasting serum glucose, insulin, and liver enzymes were assessed for 48 cases and 40 ordinary controls. Serum iron and ferritin were recorded as an indicator of iron overload Results: Fasting serum insulin, alanine transaminase [ALT] levels, aspartate transaminase [AST] levels were significantly high in thalassemia major [TM] cases than in the control group [p Conclusion: The kids with β-TM have a high glycemic disorders incidence rate, may be because of the insulin resistance due to the amplified iron burden.
format	article
author	Basma Matar Magdy Sakr Lotfy Alsehaimy Hesham Abd al-samee
author_facet	Basma Matar Magdy Sakr Lotfy Alsehaimy Hesham Abd al-samee
author_sort	Basma Matar
title	Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload
title_short	Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload
title_full	Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload
title_fullStr	Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload
title_full_unstemmed	Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload
title_sort	evaluation of serum insulin, glucose and liver function in β-thalassemia major and their correlation with iron overload
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/bcdd71df38ec4889bfe1c1ffeadfd5ac
work_keys_str_mv	AT basmamatar evaluationofseruminsulinglucoseandliverfunctioninbthalassemiamajorandtheircorrelationwithironoverload AT magdysakr evaluationofseruminsulinglucoseandliverfunctioninbthalassemiamajorandtheircorrelationwithironoverload AT lotfyalsehaimy evaluationofseruminsulinglucoseandliverfunctioninbthalassemiamajorandtheircorrelationwithironoverload AT heshamabdalsamee evaluationofseruminsulinglucoseandliverfunctioninbthalassemiamajorandtheircorrelationwithironoverload
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Evaluation of Serum Insulin, Glucose and Liver Function in β-Thalassemia Major and Their Correlation with Iron Overload

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