IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL

Abstract. We have performed immunological studies in forty-five patients who underwent lamellar keratoplasty by means of Alloplant biomaterial. Serum antibodies to eye tissue-specific antigens (bovine corneal protein (BCP)-54, lens alpha-crystallin, S-antigen) were tested, and IgG, A, M in the lacri...

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Autores principales:	R. Z. Kadyrov, E. M. Gareev, V. G. Yakovleva, N N. Kurchatova, R. Sh. Yusupova, R. E. Primov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immune status lamellar keratoplasty biomaterial «alloplant» Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bcdea857b66b4a4784d3ef4ff453fd5c
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spelling	oai:doaj.org-article:bcdea857b66b4a4784d3ef4ff453fd5c2021-11-18T08:03:43ZIMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL1563-06252313-741X10.15789/1563-0625-2012-6-513-518https://doaj.org/article/bcdea857b66b4a4784d3ef4ff453fd5c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/610https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have performed immunological studies in forty-five patients who underwent lamellar keratoplasty by means of Alloplant biomaterial. Serum antibodies to eye tissue-specific antigens (bovine corneal protein (BCP)-54, lens alpha-crystallin, S-antigen) were tested, and IgG, A, M in the lacrimal fluid were also determined, to detect cellular sensitization against same antigens, and to evaluate the levels of local non-specific inflammation. Percentage of cells activated for BCP-54 was found to be significantly decreased after surgery (p < 0.04), followed by increase to initial levels (p > 0.20) at later terms. Percentage of cells activated for lens α-crystallin was shown to be decreased upon further observation (p < 0.04). A post-surgical increase in IgG levels was revealed in lacrimal fluid (p < 0.02), followed by a decrease later on (p < 0.002). Thus, application of Alloplant biomaterial for lamellar keratoplasty does not cause any sufficient tension of specific humoral immunity against ocular tissues, as evidenced by lack of statistically significant changes of humoral and cellular immunity during post-surgical observations.R. Z. KadyrovE. M. GareevV. G. YakovlevaN N. KurchatovaR. Sh. YusupovaR. E. PrimovSPb RAACIarticleimmune statuslamellar keratoplastybiomaterial «alloplant»Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 6, Pp 513-518 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune status lamellar keratoplasty biomaterial «alloplant» Immunologic diseases. Allergy RC581-607
spellingShingle	immune status lamellar keratoplasty biomaterial «alloplant» Immunologic diseases. Allergy RC581-607 R. Z. Kadyrov E. M. Gareev V. G. Yakovleva N N. Kurchatova R. Sh. Yusupova R. E. Primov IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL
description	Abstract. We have performed immunological studies in forty-five patients who underwent lamellar keratoplasty by means of Alloplant biomaterial. Serum antibodies to eye tissue-specific antigens (bovine corneal protein (BCP)-54, lens alpha-crystallin, S-antigen) were tested, and IgG, A, M in the lacrimal fluid were also determined, to detect cellular sensitization against same antigens, and to evaluate the levels of local non-specific inflammation. Percentage of cells activated for BCP-54 was found to be significantly decreased after surgery (p < 0.04), followed by increase to initial levels (p > 0.20) at later terms. Percentage of cells activated for lens α-crystallin was shown to be decreased upon further observation (p < 0.04). A post-surgical increase in IgG levels was revealed in lacrimal fluid (p < 0.02), followed by a decrease later on (p < 0.002). Thus, application of Alloplant biomaterial for lamellar keratoplasty does not cause any sufficient tension of specific humoral immunity against ocular tissues, as evidenced by lack of statistically significant changes of humoral and cellular immunity during post-surgical observations.
format	article
author	R. Z. Kadyrov E. M. Gareev V. G. Yakovleva N N. Kurchatova R. Sh. Yusupova R. E. Primov
author_facet	R. Z. Kadyrov E. M. Gareev V. G. Yakovleva N N. Kurchatova R. Sh. Yusupova R. E. Primov
author_sort	R. Z. Kadyrov
title	IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL
title_short	IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL
title_full	IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL
title_fullStr	IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL
title_full_unstemmed	IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL
title_sort	immunological characteristics of patients with different corneal disorders treated by lamellar keratoplasty by means of a lloplant biomaterial
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/bcdea857b66b4a4784d3ef4ff453fd5c
work_keys_str_mv	AT rzkadyrov immunologicalcharacteristicsofpatientswithdifferentcornealdisorderstreatedbylamellarkeratoplastybymeansofalloplantbiomaterial AT emgareev immunologicalcharacteristicsofpatientswithdifferentcornealdisorderstreatedbylamellarkeratoplastybymeansofalloplantbiomaterial AT vgyakovleva immunologicalcharacteristicsofpatientswithdifferentcornealdisorderstreatedbylamellarkeratoplastybymeansofalloplantbiomaterial AT nnkurchatova immunologicalcharacteristicsofpatientswithdifferentcornealdisorderstreatedbylamellarkeratoplastybymeansofalloplantbiomaterial AT rshyusupova immunologicalcharacteristicsofpatientswithdifferentcornealdisorderstreatedbylamellarkeratoplastybymeansofalloplantbiomaterial AT reprimov immunologicalcharacteristicsofpatientswithdifferentcornealdisorderstreatedbylamellarkeratoplastybymeansofalloplantbiomaterial
_version_	1718422444005392384

IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH DIFFERENT CORNEAL DISORDERS TREATED BY LAMELLAR KERATOPLASTY BY MEANS OF A LLOPLANT BIOMATERIAL

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