TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

White adipose tissue can undergo a process of beiging and acquire functional characteristics similar to brown adipose tissue, including the ability to dissipate energy via uncoupled respiration. Here, Velazquez-Villegas et al. show that activation of the bile acid membrane receptor, TGR5, leads to w...

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Autores principales:	Laura A. Velazquez-Villegas, Alessia Perino, Vera Lemos, Marika Zietak, Mitsunori Nomura, Thijs Willem Hendrik Pols, Kristina Schoonjans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bce118ad1a8c4d168d327a80b1fb7582
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spelling	oai:doaj.org-article:bce118ad1a8c4d168d327a80b1fb75822021-12-02T16:56:54ZTGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue10.1038/s41467-017-02068-02041-1723https://doaj.org/article/bce118ad1a8c4d168d327a80b1fb75822018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02068-0https://doaj.org/toc/2041-1723White adipose tissue can undergo a process of beiging and acquire functional characteristics similar to brown adipose tissue, including the ability to dissipate energy via uncoupled respiration. Here, Velazquez-Villegas et al. show that activation of the bile acid membrane receptor, TGR5, leads to white adipocyte beiging by promoting mitochondrial fission.Laura A. Velazquez-VillegasAlessia PerinoVera LemosMarika ZietakMitsunori NomuraThijs Willem Hendrik PolsKristina SchoonjansNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura A. Velazquez-Villegas Alessia Perino Vera Lemos Marika Zietak Mitsunori Nomura Thijs Willem Hendrik Pols Kristina Schoonjans TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
description	White adipose tissue can undergo a process of beiging and acquire functional characteristics similar to brown adipose tissue, including the ability to dissipate energy via uncoupled respiration. Here, Velazquez-Villegas et al. show that activation of the bile acid membrane receptor, TGR5, leads to white adipocyte beiging by promoting mitochondrial fission.
format	article
author	Laura A. Velazquez-Villegas Alessia Perino Vera Lemos Marika Zietak Mitsunori Nomura Thijs Willem Hendrik Pols Kristina Schoonjans
author_facet	Laura A. Velazquez-Villegas Alessia Perino Vera Lemos Marika Zietak Mitsunori Nomura Thijs Willem Hendrik Pols Kristina Schoonjans
author_sort	Laura A. Velazquez-Villegas
title	TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
title_short	TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
title_full	TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
title_fullStr	TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
title_full_unstemmed	TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
title_sort	tgr5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bce118ad1a8c4d168d327a80b1fb7582
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TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

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