Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults

Tung-Wei Kao,1,2 Tao-Chun Peng,1 Wei-Liang Chen,1 Yu-Chiao Chi,2 Chi-Ling Chen,2 Wei-Shiung Yang2– 4 1Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; 2Graduate Institute of Clinical Medicine,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kao TW, Peng TC, Chen WL, Chi YC, Chen CL, Yang WS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	leptin dynapenia sarcopenia elderly muscle strength mass Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/bce2a84022e245428fd0d0576e733edd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bce2a84022e245428fd0d0576e733edd
record_format	dspace
spelling	oai:doaj.org-article:bce2a84022e245428fd0d0576e733edd2021-12-02T19:36:57ZHigher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults1178-7031https://doaj.org/article/bce2a84022e245428fd0d0576e733edd2021-11-01T00:00:00Zhttps://www.dovepress.com/higher-serum-leptin-levels-are-associated-with-a-reduced-risk-of-sarco-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Tung-Wei Kao,1,2 Tao-Chun Peng,1 Wei-Liang Chen,1 Yu-Chiao Chi,2 Chi-Ling Chen,2 Wei-Shiung Yang2– 4 1Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; 2Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; 3Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 4Center for Obesity, Life Style and Metabolic Surgery, National Taiwan University Hospital, Taipei, TaiwanCorrespondence: Wei-Shiung Yang Email wsyang@ntu.edu.twBackground: Leptin plays an important role in regulating the energy homeostasis of fat and muscle. Paradoxical findings existed between serum leptin levels and muscle health conditions. Here, we aimed to investigate the relationship between serum leptin levels and the risk of sarcopenia or dynapenia among older adults.Methods: Adults aged 65 and older living in the community were recruited at annual health checkups. Body composition, gait speed, and handgrip strength were examined. The cutoff values of muscle mass and strength to define sarcopenia and dynapenia were based on the consensus by the Asia Working Group of Sarcopenia in 2019. Serum leptin level was measured by an immunoassay.Results: Four hundred sixty participants (55.65% females) were enrolled. There were 16.08% and 23.91% with sarcopenia and dynapenia, respectively. Higher serum leptin levels were positively associated with muscle and fat mass but negatively associated with handgrip strength and gait speed for both sexes. In the logistic regression models adjusted for various confounders, a higher serum leptin level was associated with an increased risk of dynapenia with dose-response effects among both male and female participants (odds ratio [OR]=3.74, 95% confidence interval [CI]= 0.99– 14.17; OR= 3.32, 95% CI=1.03– 10.74, respectively), and a positive trend existed in both genders (p for trend=0.040 and 0.042, respectively). In contrast, a higher leptin level was associated with a reduced risk of sarcopenia with dose-response trends for both sexes (OR= 0.06, 95% CI=0.01– 0.48; OR= 0.26, 95% CI=0.06– 1.17, respectively) in models of multivariate logistic regression analyses, and a negative trend existed in both genders (p for trend = 0.002 and 0.023, respectively).Conclusion: A positive trend existed between the serum leptin level and the dynapenia risk, whereas it revealed a negative trend in the serum leptin level and sarcopenia risk in both male and female elderly individuals. The biological mechanisms underlying its negative association with muscle strength but its positive association with muscle mass warrants further investigation.Keywords: leptin, dynapenia, sarcopenia, elderly, muscle, strength, massKao TWPeng TCChen WLChi YCChen CLYang WSDove Medical PressarticleleptindynapeniasarcopeniaelderlymusclestrengthmassPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5817-5825 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	leptin dynapenia sarcopenia elderly muscle strength mass Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	leptin dynapenia sarcopenia elderly muscle strength mass Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Kao TW Peng TC Chen WL Chi YC Chen CL Yang WS Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults
description	Tung-Wei Kao,1,2 Tao-Chun Peng,1 Wei-Liang Chen,1 Yu-Chiao Chi,2 Chi-Ling Chen,2 Wei-Shiung Yang2– 4 1Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; 2Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; 3Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 4Center for Obesity, Life Style and Metabolic Surgery, National Taiwan University Hospital, Taipei, TaiwanCorrespondence: Wei-Shiung Yang Email wsyang@ntu.edu.twBackground: Leptin plays an important role in regulating the energy homeostasis of fat and muscle. Paradoxical findings existed between serum leptin levels and muscle health conditions. Here, we aimed to investigate the relationship between serum leptin levels and the risk of sarcopenia or dynapenia among older adults.Methods: Adults aged 65 and older living in the community were recruited at annual health checkups. Body composition, gait speed, and handgrip strength were examined. The cutoff values of muscle mass and strength to define sarcopenia and dynapenia were based on the consensus by the Asia Working Group of Sarcopenia in 2019. Serum leptin level was measured by an immunoassay.Results: Four hundred sixty participants (55.65% females) were enrolled. There were 16.08% and 23.91% with sarcopenia and dynapenia, respectively. Higher serum leptin levels were positively associated with muscle and fat mass but negatively associated with handgrip strength and gait speed for both sexes. In the logistic regression models adjusted for various confounders, a higher serum leptin level was associated with an increased risk of dynapenia with dose-response effects among both male and female participants (odds ratio [OR]=3.74, 95% confidence interval [CI]= 0.99– 14.17; OR= 3.32, 95% CI=1.03– 10.74, respectively), and a positive trend existed in both genders (p for trend=0.040 and 0.042, respectively). In contrast, a higher leptin level was associated with a reduced risk of sarcopenia with dose-response trends for both sexes (OR= 0.06, 95% CI=0.01– 0.48; OR= 0.26, 95% CI=0.06– 1.17, respectively) in models of multivariate logistic regression analyses, and a negative trend existed in both genders (p for trend = 0.002 and 0.023, respectively).Conclusion: A positive trend existed between the serum leptin level and the dynapenia risk, whereas it revealed a negative trend in the serum leptin level and sarcopenia risk in both male and female elderly individuals. The biological mechanisms underlying its negative association with muscle strength but its positive association with muscle mass warrants further investigation.Keywords: leptin, dynapenia, sarcopenia, elderly, muscle, strength, mass
format	article
author	Kao TW Peng TC Chen WL Chi YC Chen CL Yang WS
author_facet	Kao TW Peng TC Chen WL Chi YC Chen CL Yang WS
author_sort	Kao TW
title	Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults
title_short	Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults
title_full	Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults
title_fullStr	Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults
title_full_unstemmed	Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults
title_sort	higher serum leptin levels are associated with a reduced risk of sarcopenia but a higher risk of dynapenia among older adults
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/bce2a84022e245428fd0d0576e733edd
work_keys_str_mv	AT kaotw higherserumleptinlevelsareassociatedwithareducedriskofsarcopeniabutahigherriskofdynapeniaamongolderadults AT pengtc higherserumleptinlevelsareassociatedwithareducedriskofsarcopeniabutahigherriskofdynapeniaamongolderadults AT chenwl higherserumleptinlevelsareassociatedwithareducedriskofsarcopeniabutahigherriskofdynapeniaamongolderadults AT chiyc higherserumleptinlevelsareassociatedwithareducedriskofsarcopeniabutahigherriskofdynapeniaamongolderadults AT chencl higherserumleptinlevelsareassociatedwithareducedriskofsarcopeniabutahigherriskofdynapeniaamongolderadults AT yangws higherserumleptinlevelsareassociatedwithareducedriskofsarcopeniabutahigherriskofdynapeniaamongolderadults
_version_	1718376348239527936

Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults

Ejemplares similares