Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing

Abstract Serious infection caused by drug-resistant gram-negative bacteria and their secreted toxins (e.g., lipopolysaccharide) is a serious threat to human health. Thus, treatment strategies that efficiently kill bacteria and reducing the impact of their toxins simultaneously are urgently required....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zaihui Peng, Xiaochun Zhang, Long Yuan, Ting Li, Yajie Chen, Hao Tian, Dandan Ma, Jun Deng, Xiaowei Qi, Xuntao Yin
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Bacterial infection Wound healing Toxin adsorption Mesoporous copper silicate microspheres Photothermal therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/bce5f226057b4d64b99940e17db2cc09
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bce5f226057b4d64b99940e17db2cc09
record_format	dspace
spelling	oai:doaj.org-article:bce5f226057b4d64b99940e17db2cc092021-11-28T12:26:35ZIntegrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing10.1186/s12951-021-01130-w1477-3155https://doaj.org/article/bce5f226057b4d64b99940e17db2cc092021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01130-whttps://doaj.org/toc/1477-3155Abstract Serious infection caused by drug-resistant gram-negative bacteria and their secreted toxins (e.g., lipopolysaccharide) is a serious threat to human health. Thus, treatment strategies that efficiently kill bacteria and reducing the impact of their toxins simultaneously are urgently required. Herein, a novel antibacterial platform composed of a mesoporous copper silicate microsphere (CSO) core and a platelet membrane (PM) shell was prepared (CSO@PM). CSO@PM specifically targets bacteria owing to formyl peptide receptors on the PM and, combined with photothermal therapy (PTT), exhibits highly effective bacter icidal activity. Importantly, CSO@PM can adsorb lipopolysaccharide secreted by gram-negative bacteria, resulting in inflammation reduction. Thus, CSO@PM stimulates re-epithelialization and granulation-tissue formation, promoting wound healing. Moreover, this antibacterial platform exhibits no obvious toxicity at all the test concentrations in vitro and in vivo. Thus, CSO@PM exhibits a robust antibacterial effect and a strong toxin-adsorption capacity, facilitating the clinical treatment of many bacterial infections and the development of next-generation antibacterial nanoagents. Graphical AbstractZaihui PengXiaochun ZhangLong YuanTing LiYajie ChenHao TianDandan MaJun DengXiaowei QiXuntao YinBMCarticleBacterial infectionWound healingToxin adsorptionMesoporous copper silicate microspheresPhotothermal therapyBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bacterial infection Wound healing Toxin adsorption Mesoporous copper silicate microspheres Photothermal therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Bacterial infection Wound healing Toxin adsorption Mesoporous copper silicate microspheres Photothermal therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5 Zaihui Peng Xiaochun Zhang Long Yuan Ting Li Yajie Chen Hao Tian Dandan Ma Jun Deng Xiaowei Qi Xuntao Yin Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing
description	Abstract Serious infection caused by drug-resistant gram-negative bacteria and their secreted toxins (e.g., lipopolysaccharide) is a serious threat to human health. Thus, treatment strategies that efficiently kill bacteria and reducing the impact of their toxins simultaneously are urgently required. Herein, a novel antibacterial platform composed of a mesoporous copper silicate microsphere (CSO) core and a platelet membrane (PM) shell was prepared (CSO@PM). CSO@PM specifically targets bacteria owing to formyl peptide receptors on the PM and, combined with photothermal therapy (PTT), exhibits highly effective bacter icidal activity. Importantly, CSO@PM can adsorb lipopolysaccharide secreted by gram-negative bacteria, resulting in inflammation reduction. Thus, CSO@PM stimulates re-epithelialization and granulation-tissue formation, promoting wound healing. Moreover, this antibacterial platform exhibits no obvious toxicity at all the test concentrations in vitro and in vivo. Thus, CSO@PM exhibits a robust antibacterial effect and a strong toxin-adsorption capacity, facilitating the clinical treatment of many bacterial infections and the development of next-generation antibacterial nanoagents. Graphical Abstract
format	article
author	Zaihui Peng Xiaochun Zhang Long Yuan Ting Li Yajie Chen Hao Tian Dandan Ma Jun Deng Xiaowei Qi Xuntao Yin
author_facet	Zaihui Peng Xiaochun Zhang Long Yuan Ting Li Yajie Chen Hao Tian Dandan Ma Jun Deng Xiaowei Qi Xuntao Yin
author_sort	Zaihui Peng
title	Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing
title_short	Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing
title_full	Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing
title_fullStr	Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing
title_full_unstemmed	Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing
title_sort	integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing
publisher	BMC
publishDate	2021
url	https://doaj.org/article/bce5f226057b4d64b99940e17db2cc09
work_keys_str_mv	AT zaihuipeng integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT xiaochunzhang integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT longyuan integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT tingli integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT yajiechen integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT haotian integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT dandanma integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT jundeng integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT xiaoweiqi integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing AT xuntaoyin integratedendotoxinadsorptionandantibacterialpropertiesofplateletmembranecoatedcoppersilicatehollowmicrospheresforwoundhealing
_version_	1718407979348262912

Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing

Ejemplares similares