Brain water as a function of age and weight in normal rats.

Rats are frequently used for studying water content of normal and injured brain, as well as changes in response to various osmotherapeutic regimens. Magnetic resonance imaging in humans has shown that brain water content declines with age as a result of progressive myelination and other processes. T...

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Autores principales:	Allan Gottschalk, Susanna Scafidi, Thomas J K Toung
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bce8882e458143ababf35fae3a5724ce
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spelling	oai:doaj.org-article:bce8882e458143ababf35fae3a5724ce2021-12-02T20:08:14ZBrain water as a function of age and weight in normal rats.1932-620310.1371/journal.pone.0249384https://doaj.org/article/bce8882e458143ababf35fae3a5724ce2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0249384https://doaj.org/toc/1932-6203Rats are frequently used for studying water content of normal and injured brain, as well as changes in response to various osmotherapeutic regimens. Magnetic resonance imaging in humans has shown that brain water content declines with age as a result of progressive myelination and other processes. The purpose of this study was to quantify changes in brain water content during rat development and aging. Brain water content was measured by standard techniques in 129 normal male Sprague-Dawley rats that ranged in age (weight) from 13 to 149 days (18 to 759 g). Overall, the results demonstrated a decrease in water content from 85.59% to 76.56% with increasing age (weight). Nonlinear allometric functions relating brain water to age and weight were determined. These findings provide age-related context for prior rat studies of brain water, emphasize the importance of using similarly aged controls in studies of brain water, and indicate that age-related changes in brain water content are not specific to humans.Allan GottschalkSusanna ScafidiThomas J K ToungPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0249384 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Allan Gottschalk Susanna Scafidi Thomas J K Toung Brain water as a function of age and weight in normal rats.
description	Rats are frequently used for studying water content of normal and injured brain, as well as changes in response to various osmotherapeutic regimens. Magnetic resonance imaging in humans has shown that brain water content declines with age as a result of progressive myelination and other processes. The purpose of this study was to quantify changes in brain water content during rat development and aging. Brain water content was measured by standard techniques in 129 normal male Sprague-Dawley rats that ranged in age (weight) from 13 to 149 days (18 to 759 g). Overall, the results demonstrated a decrease in water content from 85.59% to 76.56% with increasing age (weight). Nonlinear allometric functions relating brain water to age and weight were determined. These findings provide age-related context for prior rat studies of brain water, emphasize the importance of using similarly aged controls in studies of brain water, and indicate that age-related changes in brain water content are not specific to humans.
format	article
author	Allan Gottschalk Susanna Scafidi Thomas J K Toung
author_facet	Allan Gottschalk Susanna Scafidi Thomas J K Toung
author_sort	Allan Gottschalk
title	Brain water as a function of age and weight in normal rats.
title_short	Brain water as a function of age and weight in normal rats.
title_full	Brain water as a function of age and weight in normal rats.
title_fullStr	Brain water as a function of age and weight in normal rats.
title_full_unstemmed	Brain water as a function of age and weight in normal rats.
title_sort	brain water as a function of age and weight in normal rats.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/bce8882e458143ababf35fae3a5724ce
work_keys_str_mv	AT allangottschalk brainwaterasafunctionofageandweightinnormalrats AT susannascafidi brainwaterasafunctionofageandweightinnormalrats AT thomasjktoung brainwaterasafunctionofageandweightinnormalrats
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Brain water as a function of age and weight in normal rats.

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