Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells in the majority of patients with leukemia but not during normal blood formation. Here, the authors report a mouse model with conditional Cdx2 expression showing de novo leukemic transformation, and use it to optimiz...

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Autores principales:	Therese Vu, Jasmin Straube, Amy H. Porter, Megan Bywater, Axia Song, Victoria Ling, Leanne Cooper, Gabor Pali, Claudia Bruedigam, Sebastien Jacquelin, Joanne Green, Graham Magor, Andrew Perkins, Alistair M. Chalk, Carl R. Walkley, Florian H. Heidel, Pamela Mukhopadhyay, Nicole Cloonan, Stefan Gröschel, Jan-Philipp Mallm, Stefan Fröhling, Claudia Scholl, Steven W. Lane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bceafc18d13641ee9c5212ab1db8af73
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spelling	oai:doaj.org-article:bceafc18d13641ee9c5212ab1db8af732021-12-02T17:40:29ZHematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia10.1038/s41467-020-16840-22041-1723https://doaj.org/article/bceafc18d13641ee9c5212ab1db8af732020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16840-2https://doaj.org/toc/2041-1723The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells in the majority of patients with leukemia but not during normal blood formation. Here, the authors report a mouse model with conditional Cdx2 expression showing de novo leukemic transformation, and use it to optimize treatment in high-risk AML.Therese VuJasmin StraubeAmy H. PorterMegan BywaterAxia SongVictoria LingLeanne CooperGabor PaliClaudia BruedigamSebastien JacquelinJoanne GreenGraham MagorAndrew PerkinsAlistair M. ChalkCarl R. WalkleyFlorian H. HeidelPamela MukhopadhyayNicole CloonanStefan GröschelJan-Philipp MallmStefan FröhlingClaudia SchollSteven W. LaneNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Therese Vu Jasmin Straube Amy H. Porter Megan Bywater Axia Song Victoria Ling Leanne Cooper Gabor Pali Claudia Bruedigam Sebastien Jacquelin Joanne Green Graham Magor Andrew Perkins Alistair M. Chalk Carl R. Walkley Florian H. Heidel Pamela Mukhopadhyay Nicole Cloonan Stefan Gröschel Jan-Philipp Mallm Stefan Fröhling Claudia Scholl Steven W. Lane Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
description	The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells in the majority of patients with leukemia but not during normal blood formation. Here, the authors report a mouse model with conditional Cdx2 expression showing de novo leukemic transformation, and use it to optimize treatment in high-risk AML.
format	article
author	Therese Vu Jasmin Straube Amy H. Porter Megan Bywater Axia Song Victoria Ling Leanne Cooper Gabor Pali Claudia Bruedigam Sebastien Jacquelin Joanne Green Graham Magor Andrew Perkins Alistair M. Chalk Carl R. Walkley Florian H. Heidel Pamela Mukhopadhyay Nicole Cloonan Stefan Gröschel Jan-Philipp Mallm Stefan Fröhling Claudia Scholl Steven W. Lane
author_facet	Therese Vu Jasmin Straube Amy H. Porter Megan Bywater Axia Song Victoria Ling Leanne Cooper Gabor Pali Claudia Bruedigam Sebastien Jacquelin Joanne Green Graham Magor Andrew Perkins Alistair M. Chalk Carl R. Walkley Florian H. Heidel Pamela Mukhopadhyay Nicole Cloonan Stefan Gröschel Jan-Philipp Mallm Stefan Fröhling Claudia Scholl Steven W. Lane
author_sort	Therese Vu
title	Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
title_short	Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
title_full	Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
title_fullStr	Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
title_full_unstemmed	Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
title_sort	hematopoietic stem and progenitor cell-restricted cdx2 expression induces transformation to myelodysplasia and acute leukemia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bceafc18d13641ee9c5212ab1db8af73
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Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

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