A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing

A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing

Abstract Novel modalities such as PROTAC and RNAi have the ability to inadvertently alter the abundance of endogenous proteins. Currently available in vitro secondary pharmacology assays, which evaluate off-target binding or activity of small molecules, do not fully assess the off-target effects of...

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Autores principales: Xin Liu, Ye Zhang, Lucas D. Ward, Qinghong Yan, Tanggis Bohnuud, Rocio Hernandez, Socheata Lao, Jing Yuan, Fan Fan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/bceb4a3a9b72451bb8dd1f5b780cc4d7
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